Cytotoxic sesquiterpene lactones from Saussurea calcicola

被引：37

作者：

Choi, SZ

Choi, SU

Lee, KR

机构：

[1] Sungkyunkwan Univ, Coll Pharm, Nat Prod Lab, Suwon 440746, South Korea

[2] Korea Res Inst Chem Technol, Taejon 305606, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2005年 / 28卷 / 10期

关键词：

Saussurea calcicola; Compositae; sesquiterpene lactone; cytotoxicity;

D O I：

10.1007/BF02972976

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Seven sesquiterpene lactones were isolated by the chromatographic separation of the MeOH extract of the aerial parts of Saussurea calcicola (Compositae). Their structures were determined spectroscopically to be cynaropicrin (1), arguerin B (2), cebellin F (3), 8 alpha-hydroxy-11 alpha, 13-dihydrozaluzanin C (4), desacylcynaropicrin (5), 3 beta-hydroxy-8 alpha-epoxymethylacriloiloxy-4(15),10(14),11(13)-trien-guaian-6,12-olide (6), and kandavanolide (7). Compounds 1 and 2 showed significant cytotoxicity against five cultured human tumor cell lines with ED50 values ranging from 0.23 similar to 1.72 mu g/mL.

引用

页码：1142 / 1146

页数：5

共 21 条

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