The autoimmune T and B cell repertoires in monozygotic twins discordant for myasthenia gravis

被引：10

作者：

Kakoulidou, M

Åhlberg, R

Yi, Q

Giscombe, R

Pirskanen, R

Lefvert, AK

机构：

[1] Karolinska Inst, Dept Neurol, Stockholm, Sweden

[2] Karolinska Inst, Dept Med, Stockholm, Sweden

[3] Karolinska Inst, Ctr Mol Med, Immunol Res Lab, Stockholm, Sweden

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2004年 / 148卷 / 1-2期

关键词：

myasthenia gravis; twin; B-lymphocyte; auto antibodies; T lymphocyte;

D O I：

10.1016/j.jneuroim.2003.09.019

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Two pairs of monozygotic twins, discordant for myasthenia gravis (MG) for more than 30 years, were studied regarding T cell and antibody reactivity against disease related autoantigens, the acetylcholine receptor, one idiotypic and one anti-idiotypic human monoclonal antibody. The healthy and myasthenic twins had very similar autoantibody repertoires. IgG fractions from both healthy and myasthenic twins had the same capacity to decrease the free acetylcholine receptor content in mice after passive transfer. In comparison with their myasthenic sisters, the healthy twins had lower T cell responses against the acetylcholine receptor. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：183 / 191

页数：9

共 54 条

[1] TREATMENT OF MYASTHENIA-GRAVIS WITH ANTI-CD4 ANTIBODY - IMPROVEMENT CORRELATES TO DECREASED T-CELL AUTOREACTIVITY [J].