Glial cell line-derived neurotrophic factor (GDNF) family ligands reduce the sensitivity of neuroblastoma cells to pharmacologically induced cell death, growth arrest and differentiation

被引：22

作者：

Hansford, LA

Marshall, GA ^{[1
]}

机构：

[1] Childrens Canc Inst Australia Med Res, Sydney, NSW, Australia

[2] Sydney Childrens Hosp, Ctr Childrens Canc & Blood Disorders, Randwick, NSW 2031, Australia

来源：

NEUROSCIENCE LETTERS | 2005年 / 389卷 / 02期

基金：

英国医学研究理事会;

关键词：

neuroblastoma; glial cell line-derived neurotrophic factor (GDNF) family ligands; Ret tyrosine kinase; GFR alpha co-receptor; cell growth; differentiation therapy;

D O I：

10.1016/j.neulet.2005.07.034

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The glial cell line-derived neurotrophic factor (GDNF) family of ligands play essential roles in promoting normal neural crest differentiation during embryogenesis, and, may have a therapeutic role in malignancies of neural crest origin, such as neuroblastoma. However, we report here that GDNF and neurturin blocked the growth inhibitory and neuritogenic effects of all-trans-retinoic acid in neuroblastoma cells in vitro. GDNF caused neuroblastoma cells to proliferate in the presence of a range of cytotoxic chemotherapeutic agents at low concentrations. Thus, our findings suggest a role for GDNF signaling in promoting resistance to differentiation or cytotoxic therapy of neuroblastoma, and, preclude their use in this neural crest tumor. (C) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：77 / 82

页数：6

共 24 条

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