Enzymatic syntheses of 6-(4H-selenolo[3,2-b]pyrrolyl)-L-alanine, 4-(6H-selenolo [2,3-b]pyrrolyl)-L-alanine, and 6-(4H-furo[3,2-b]pyrrolyl)-L-alanine

被引：24

作者：

Welch, M

Phillips, RS ^{[1
]}

机构：

[1] Univ Georgia, Dept Chem, Athens, GA 30602 USA

[2] Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA

[3] Univ Georgia, Ctr Metalloenzyme Studies, Athens, GA 30602 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(99)00067-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

6-(4H-Selenolo[3,2-b]pyrrolyl)-L-alanine 1, 4-(6H-selenolo[2,3-b]pyrrolyl)-L-alanine 2, and 6-(4H-furo[3,2-b]pyrrolyl)-L-alanine 3 have been synthesized via reactions of selenolo[3,2-b]pyrrole, selenolo[2,3-b]pyrrole, and furo[3,2-b]pyrrole, respectively, with L-serine. The reactions are catalyzed by Salmonella typhimurium tryptophan synthase. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：637 / 640

页数：4

共 7 条

[1]

Besse D, 1997, BIOL CHEM, V378, P211

[2]

FAIRWELL T, 1994, P 42 ASMS C MASS SPE, P640

[3] ENZYMATIC-SYNTHESIS OF THIA-L-TRYPTOPHANS [J].