Prevalence and degree of expression of the carbapenemase gene (cfiA) among clinical isolates of Bacteroides fragilis in Nottingham, UK

被引：27

作者：

Edwards, R ^{[1
]}

Hawkyard, CV

Garvey, MT

Greenwood, D

机构：

[1] Univ Nottingham Hosp, Queens Med Ctr, Div Microbiol, Nottingham NG7 2UH, England

[2] Univ Nottingham Hosp, Queens Med Ctr, PHLS Lab, Nottingham NG7 2UH, England

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1999年 / 43卷 / 02期

关键词：

D O I：

10.1093/jac/43.2.273

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The carbapenemase gene (cfiA) was detected in 12 (6.9%) out of 175 clinical isolates of Bacteroides fragilis from Nottingham, three times the frequency reported from France. Only one gene copy was present in all cases. Eleven (6.3%) of the cfiA-positive isolates were susceptible to imipenem or meropenem (MIC < 8 mg/L); strains of this type have the potential to convert to high-level resistance. One isolate (0.6%) displayed resistance to both carbapenem antibiotics and was associated with specific carbapenemase activity six times that of the sensitive isolates.

引用

页码：273 / 276

页数：4

共 10 条

[1] Ausubel FM., 1994, Curr. Protoc. Mol. Biol
[2] SUSCEPTIBILITY PATTERNS AND RESISTANCE TO IMIPENEM IN THE BACTEROIDES-FRAGILIS GROUP SPECIES IN JAPAN - A 4-YEAR STUDY
BANDOH, K
UENO, K
WATANABE, K
KATO, N
[J]. CLINICAL INFECTIOUS DISEASES, 1993, 16 : S382 - S386
[3] BETA-LACTAMASE-MEDIATED IMIPENEM RESISTANCE IN BACTEROIDES-FRAGILIS
CUCHURAL, GJ
MALAMY, MH
TALLY, FP
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1986, 30 (05) : 645 - 648
[4] AN INVESTIGATION OF BETA-LACTAMASES FROM CLINICAL ISOLATES OF BACTEROIDES SPECIES
EDWARDS, R
GREENWOOD, D
[J]. JOURNAL OF MEDICAL MICROBIOLOGY, 1992, 36 (02) : 89 - 95
[5] Changes in beta-lactam antibiotic susceptibility and beta-lactamase production of clinical isolates of Bacteroides and Prevotella species over a 9 year period
Edwards, R
Thirlwell, D
Greenwood, D
[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1996, 37 (03) : 636 - 638
[6] GENOTYPIC IDENTIFICATION OF 2 GROUPS WITHIN THE SPECIES BACTEROIDES-FRAGILIS BY RIBOTYPING AND BY ANALYSIS OF PCR-GENERATED FRAGMENT PATTERNS AND INSERTION-SEQUENCE CONTENT
PODGLAJEN, I
BREUIL, J
CASIN, I
COLLATZ, E
[J]. JOURNAL OF BACTERIOLOGY, 1995, 177 (18) : 5270 - 5275
[7] INSERTION OF A NOVEL DNA-SEQUENCE, IS-1186, UPSTREAM OF THE SILENT CARBAPENEMASE GENE CFIA, PROMOTES EXPRESSION OF CARBAPENEM RESISTANCE IN CLINICAL ISOLATES OF BACTEROIDES-FRAGILIS
PODGLAJEN, I
BREUIL, J
COLLATZ, E
[J]. MOLECULAR MICROBIOLOGY, 1994, 12 (01) : 105 - 114
[8] A SILENT CARBAPENEMASE GENE IN STRAINS OF BACTEROIDES-FRAGILIS CAN BE EXPRESSED AFTER A ONE-STEP MUTATION
PODGLAJEN, I
BREUIL, J
BORDON, F
GUTMANN, L
COLLATZ, E
[J]. FEMS MICROBIOLOGY LETTERS, 1992, 91 (01) : 21 - 29
[9] SEQUENCING THE GENE FOR AN IMIPENEM-CEFOXITIN-HYDROLYZING ENZYME (CFIA) FROM BACTEROIDES-FRAGILIS TAL2480 REVEALS STRONG SIMILARITY BETWEEN CFIA AND BACILLUS-CEREUS BETA-LACTAMASE .2.
THOMPSON, JS
MALAMY, MH
[J]. JOURNAL OF BACTERIOLOGY, 1990, 172 (05) : 2584 - 2593
[10] SIMULTANEOUS RESISTANCE TO METRONIDAZOLE, CO-AMOXICLAV, AND IMIPENEM IN CLINICAL ISOLATE OF BACTEROIDES-FRAGILIS
TURNER, P
EDWARDS, R
WESTON, V
GAZIS, A
ISPAHANI, P
GREENWOOD, D
[J]. LANCET, 1995, 345 (8960): : 1275 - 1277

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