Effects of selected minerals on leptin secretion in streptozotocin-induced hyperglycemic mice

被引：10

作者：

Chen, MD

Yang, VC

Alexander, PS

Lin, PY

Song, YM

机构：

[1] Taichung Vet Gen Hosp, Dept Med Labs, Biochem Sect, Taichung 40705, Taiwan

[2] Tunghai Univ, Dept Biol, Taichung 40705, Taiwan

[3] Tunghai Univ, Dept Chem, Taichung 40705, Taiwan

来源：

EXPERIMENTAL BIOLOGY AND MEDICINE | 2001年 / 226卷 / 09期

关键词：

leptin; lithium; magnesium; vanadium; zinc;

D O I：

10.1177/153537020122600905

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

The effects of lithium, magnesium, vanadate, and zinc on leptinemia and leptin secretion by adipose tissue were investigated in streptozotocin-(STZ) induced hyperglycemic mice. After the administration of studied minerals in drinking water for 4 weeks, fasting serum leptin concentrations were elevated, accompanied by normoglycemia in STZ-injected mice, regardless which mineral was provided (P < 0.05). However, the in vitro administration of lithium, magnesium, and vanadate did not significantly influence the leptin secretion of adipose tissue. A low zinc treatment (0.1 mM) augmented, whereas both a pharmacological treatment of zinc (1 mM) and zinc depletion (1 mM TPEN) attenuated, leptin secretion (P < 0.05). The present study shows that STZ-induced hyperglycemic mice have hypoleptinemia and reduced leptin secretion by adipose tissue. Moreover, these defects can be improved by a moderate zinc administration.

引用

页码：836 / 840

页数：5

共 35 条

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