A study on the correlation between IL1RAPL1 and human cognitive ability

被引：18

作者：

Gao, Xiaocai ^{[1
,2
,3
]}

Xi, Gengsi ^{[1
]}

Niu, Yinbo ^{[2
,3
]}

Zhang, Shumiao ^{[2
,3
]}

Fu, Ruijuan ^{[2
,3
]}

Zheng, Zijian ^{[1
,2
,3
]}

Zhang, Kejin ^{[2
,3
]}

Lv, Shumin ^{[1
]}

He, Hui ^{[1
]}

Xue, Min ^{[2
,3
]}

Zhang, Fuchang ^{[2
,3
]}

机构：

[1] Shaanxi Normal Univ, Coll Life Sci, Xian 710062, Shaanxi, Peoples R China

[2] NW Univ Xian, Key Lab Resource Biol & Biotechnol Western China, Minist Educ, Xian 710069, Shaanxi, Peoples R China

[3] NW Univ Xian, Inst Populat & Hlth, Coll Life Sci, Xian 710069, Shaanxi, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2008年 / 438卷 / 02期

基金：

中国国家自然科学基金;

关键词：

IL1RAPL1; gene polymorphism; cognition; memory and concentration;

D O I：

10.1016/j.neulet.2008.03.084

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study aimed to investigate the effects of IL1RAPL1 on the human cognitive ability. Four genetic marker sites, i.e., DXS1218, DXS9896, rs6526806 and rs12847959 on IL1RAPL1 were genotyped in 332 Qinba Mountain Area children. Meanwhile, a cognition test with a C-WISC scale was performed to study the relationship of genotype with cognition test scores. Results indicated that genotypes of DXS1218, DXS9896 and rs12847959 were associated with memory/concentration factor intelligence quotient (IQ) (P = 0.027, 0.042, 0.029, respectively). DXS1218 also associated with full IQ, verbal 10, and performance IQ (P = 0.006, 0.014, 0.006, respectively). rs12847959 were related to verbal comprehension factor and perceptual organization factor IQ (P = 0.021, 0.043, respectively). Further study on rat brain revealed that Il1rapl was mainly expressed in memory/concentration-associated encephalic regions, such as hippocampus, dentate fascia, osmesis perithelium, and piriform cortex. mRNA expression levels of Il1rapl in brains of rats with different learning and memory abilities showed significant difference. Combined data suggested that IL1RAPL1 affected human cognitive ability to some extent, especially the memory and concentration capability. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：163 / 167

页数：5

共 26 条

[1] Impaired interleukin-1 signaling is associated with deficits in hippocampal memory processes and neural plasticity [J].

Avital, A ;

Goshen, I ;

Kamsler, A ;

Segal, M ;

Iverfeldt, K ;

Richter-Levin, G ;

Yirmiya, R .

HIPPOCAMPUS, 2003, 13 (07) :826-834

[2] A SYNAPTIC MODEL OF MEMORY - LONG-TERM POTENTIATION IN THE HIPPOCAMPUS [J].

BLISS, TVP ;

COLLINGRIDGE, GL .

NATURE, 1993, 361 (6407) :31-39

[3] Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family - Delineation of a new class of IL-1R-related proteins based on signaling [J].

Born, TL ;

Smith, DE ;

Garka, KE ;

Renshaw, BR ;

Bertles, JS ;

Sims, JE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (39) :29946-29954

[4]

Cai T., 1993, MANUAL WECHSLER INTE

[5] A new member of the IL-1 receptor family highly expressed in hippocampus and involved in X-linked mental retardation [J].

Carrié, A ;

Jun, L ;

Bienvenu, T ;

Vinet, MC ;

McDonell, N ;

Couvert, P ;

Zemni, R ;

Cardona, A ;

Van Buggenhout, G ;

Frints, S ;

Hamel, B ;

Moraine, C ;

Ropers, HH ;

Strom, T ;

Howell, GR ;

Whittaker, A ;

Ross, MT ;

Kahn, A ;

Fryns, JP ;

Beldjord, C ;

Marynen, P ;

Chelly, J .

NATURE GENETICS, 1999, 23 (01) :25-31

[6] SEROTONERGIC MODULATION OF CHOLINERGIC FUNCTION IN THE CENTRAL-NERVOUS-SYSTEM - COGNITIVE IMPLICATIONS [J].

CASSEL, JC ;

JELTSCH, H .

NEUROSCIENCE, 1995, 69 (01) :1-41

[7] Expression of interleukin-1 genes and interleukin-1 receptors in the mouse brain after hippocampal injury [J].

Gabellec, MM ;

Crumeyrolle-Arias, M ;

Le Saux, F ;

Auriou, N ;

Jacque, C ;

Haour, F .

NEUROSCIENCE RESEARCH, 1999, 33 (04) :251-260

[8]

GONG YX, 1992, CHINESE WECHSLERE YO

[9] Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein [J].

Huang, JN ;

Gao, X ;

Li, S ;

Cao, ZD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (24) :12829-12832

[10] Molecular and comparative genetics of mental retardation [J].

Inlow, JK ;

Restifo, LL .

GENETICS, 2004, 166 (02) :835-881

← 1 2 3 →