Calcium and phosphate homeostasis: Concerted interplay of new regulators

被引:141
作者
Renkema, Kirsten Y. [1 ]
Alexander, R. Todd [1 ]
Bindels, Rene J. [1 ]
Hoenderop, Joost G. [1 ]
机构
[1] Radboud Univ Nijmegen, Med Ctr, Dept Physiol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, Netherlands
基金
加拿大健康研究院;
关键词
1,25-Dihydroxyvitamin-D-3; calcium; fibroblast growth factor 23; klotho; phosphate; sodium-phosphate cotransporter; TRPV5; TRPV6;
D O I
10.1080/07853890701689645
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Calcium (Ca2+) and phosphate (P-i) are essential to many vital physiological processes. Consequently the maintenance of Ca2+ and Pi homeostasis is essential to a healthy existence. This occurs through the concerted action of intestinal, renal, and skeletal regulatory mechanisms. Ca2+ and Pi handling by these organs is under tight hormonal control. Disturbances in their homeostasis have been linked to pathophysiological disorders including chronic renal insufficiency, kidney stone formation, and bone abnormalities. Importantly, the kidneys fine-tune the amount of Ca2+ and Pi retained in the body by altering their (re)absorption from the glomerular filtrate. The ion transport proteins involved in this process have been studied extensively. Recently, new key players have been identified in the regulation of the Ca2+ and Pi balance. Novel regulatory mechanisms and their implications were introduced for the antiaging hormone klotho and fibroblast growth factor member 23 (FGF23). Importantly, transgenic mouse models, exhibiting disturbances in Ca2+ and Pi balance, have been of great value in the elucidation of klotho and FGF23 functioning. This review highlights the current knowledge and ongoing research into Ca2+ and Pi homeostasis, emphasizing findings from several relevant knockout mouse models.
引用
收藏
页码:82 / 91
页数:10
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