The La antigen associates with the human telomerase ribonucleoprotein and influences telomere length in vivo

被引：44

作者：

Ford, LP ^{[1
]}

Shay, JW ^{[1
]}

Wright, WE ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Cell Biol, Dallas, TX 75390 USA

来源：

RNA | 2001年 / 7卷 / 08期

关键词：

aging; autoimmunity; cancer; hTR; RNP; telomere length homeostasis;

D O I：

10.1017/S1355838201010159

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

La is an important component of ribonucleoprotein complexes and telomerase Is a ribonucleoprotein that compensates for the shortening of the ends of linear DNA by adding telomeric repeats onto the ends of chromosomes by using an integral RNA as the template. We have identified a direct and specific interaction between La and the RNA component of human telomerase. Antibodies specific to La precipitate the human telomerase ribonucleoprotein complex derived from tumor cells, telomerase immortalized normal cells, and in vitro transformed cells. Overexpression of La in both experimentally immortalized human cells and prostate cancer cells results in gradual telomere shortening. Our results demonstrate that La can associate with telomerase and its expression level can influence telomere homeostasis in vivo.

引用

页码：1068 / 1075

页数：8

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