Sudden cardiac death secondary to antidepressant and antipsychotic drugs

被引:80
作者
Sicouri, Serge [1 ]
Antzelevitch, Charles [1 ]
机构
[1] Masonic Med Res Lab, Utica, NY 13501 USA
关键词
antidepressants; antipsychotics; arrhythmias; Brugada syndrome; long QT syndrome; sudden cardiac death;
D O I
10.1517/14740338.7.2.181
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
A number of antipsychotic and antidepressant drugs are known to increase the risk of ventricular arrhythmias and sudden cardiac death. Based largely on a concern over QT prolongation and the development of life-threatening arrhythmias, a number of antipsychotic drugs have been temporarily or permanently withdrawn from the market or their use restricted. Some antidepressants and antipsychotics have been linked to QT prolongation and the development of Torsade de pointes arrhythmias, whereas others have been associated with a Brugada syndrome phenotype and the development of polymorphic ventricular arrhythmias. This review examines the mechanisms and predisposing factors underlying the development of cardiac arrhythmias, and sudden cardiac death, associated with antidepressant and antipsychotic drugs in clinical use.
引用
收藏
页码:181 / 194
页数:14
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