Adeno-Associated Virus Antibody Profiles in Newborns, Children, and Adolescents

被引：262

作者：

Calcedo, Roberto ^{[1
]}

Morizono, Hiroki ^{[2
]}

Wang, Lili ^{[1
]}

McCarter, Robert ^{[3
]}

He, Jianping ^{[3
]}

Jones, David ^{[2
]}

Batshaw, Mark L. ^{[2
]}

Wilson, James M. ^{[1
]}

机构：

[1] Univ Penn, Dept Pathol & Lab Med, Gene Therapy Program, Philadelphia, PA 19104 USA

[2] Childrens Natl Med Ctr, Med Genet Res Ctr, Childrens Res Inst, Washington, DC 20010 USA

[3] Childrens Natl Med Ctr, Ctr Clin & Community Res, Childrens Res Inst, Washington, DC 20010 USA

来源：

CLINICAL AND VACCINE IMMUNOLOGY | 2011年 / 18卷 / 09期

关键词：

HUMAN GENE-THERAPY; VIRAL VECTORS; T-CELLS; SEROTYPE-2; LIVER; TRANSDUCTION; EXPRESSION; MICE;

D O I：

10.1128/CVI.05107-11

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neutralizing antibodies (NAb) to an adeno-associated virus (AAV) vector due to previous natural infection with wild-type AAV can significantly limit gene transfer. NAb titers to AAV serotype 2 (AAV2) and AAV8 in human subjects (0 to 18 years) were studied. NAb prevalence is moderate at birth, decreases markedly from 7 to 11 months, and then progressively increases through childhood and adolescence.

引用

页码：1586 / 1588

页数：3

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