A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection

被引：163

作者：

Casanova, Jean-Laurent ^{[1
,2
,3
,4
,5
]}

Su, Helen C. ^{[6
]}

机构：

[1] Rockefeller Unvers, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, New York, NY 10065 USA

[2] Howard Hughes Med Inst, New York, NY 10065 USA

[3] Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM, Paris, France

[4] Univ Paris, Imagine Inst, Paris, France

[5] Necker Hosp Sick Children, AP HP, Pediat Hematol & Immunol Unit, Paris, France

[6] NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIA, 9000 Rockville Pike, Bethesda, MD 20892 USA

来源：

CELL | 2020年 / 181卷 / 06期

基金：

美国国家卫生研究院;

关键词：

RESISTANCE; INFLUENZA;

D O I：

10.1016/j.cell.2020.05.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from silent infection to lethal disease. The role of human genetics in determining clinical response to the virus remains unclear. Studies of outliers-individuals remaining uninfected despite viral exposure and healthy young patients with lifethreatening disease-present a unique opportunity to reveal human genetic determinants of infection and disease.

引用

页码：1194 / 1199

页数：6

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