Is carbamazepine teratogenic? A prospective controlled study of 210 pregnancies

被引：56

作者：

Diav-Citrin, O

Shechtman, S

Arnon, J

Ornoy, A

机构：

[1] Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Anat & Cell Biol, Lab Teratol, IL-91120 Jerusalem, Israel

[2] Israeli Teratogen Informat Serv, Jerusalem, Israel

[3] Israeli Minist Hlth, Jerusalem, Israel

来源：

NEUROLOGY | 2001年 / 57卷 / 02期

关键词：

D O I：

10.1212/WNL.57.2.321

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The Israeli Teratogen Information Service prospectively followed up 210 pregnancies with First trimester carbamazepine exposure. Pregnancy outcome was compared with that of two overlapping controls, matched and general (n = 629), exposed to nonteratogenic agents. Our study suggests a twofold increase in the rate of major congenital anomalies (12/160 [carbamazepine] versus 18/560 [general control]; relative risk 2.24; 95% CI 1.1-4.56) and a birth weight reduction of approximately 250 g after in utero exposure to carbamazepine.

引用

页码：321 / 324

页数：4

共 10 条

[1] Malformations in offspring of women with epilepsy: A prospective study [J].