Genetic predisposition for adult lactose intolerance and relation to diet, bone density, and bone fractures

被引：114

作者：

Obermayer-Pietsch, BM

Bonelli, CM

Walter, DE

Kuhn, RJ

Fahrleitner-Pammer, A

Berghold, A

Goessler, W

Stepan, V

Dobnig, H

Leb, G

Renner, W

机构：

[1] Graz Univ, Dept Internal Med, Div Endocrinol & Nucl Med, A-8036 Graz, Austria

[2] Graz Univ, Inst Med Informat Stat & Documentat, A-8036 Graz, Austria

[3] Karl Franzens Univ Graz, Inst Chem Analyt Chem, Graz, Austria

[4] Karl Franzens Univ Graz, Clin Inst Med & Lab Anal, Graz, Austria

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 01期

关键词：

aging; gene association; polymorphisms; epidemiology; menopause; nutrition; osteoporosis; lactose intolerance; calcium absorption; bone mineral density; bone fractures;

D O I：

10.1359/JBMR.0301207

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Evidence that genetic disposition for adult lactose intolerance significantly affects calcium intake, bone density, and fractures in postmenopausal women is presented. PCR-based genotyping of lactase gene polymorphisms may complement diagnostic procedures to identify persons at risk for both lactose malabsorption and osteoporosis.

引用

页码：42 / 47

页数：6

共 34 条

[1] OSTEOPOROSIS INTESTINAL LACTASE DEFICIENCY AND LOW DIETARY CALCIUM INTAKE [J].