The inositol 1,4,5-trisphosphate receptors

被引：178

作者：

Bezprozvanny, I ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Physiol, Dallas, TX 75390 USA

来源：

CELL CALCIUM | 2005年 / 38卷 / 3-4期

关键词：

calcium signaling; structure-function; ion channels; calcium imaging; planar lipid bilayers; mutagenesis;

D O I：

10.1016/j.ceca.2005.06.030

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The inositol (1,4,5)-trisphosphate receptors (InsP(3)R) are the intracellular calcium (Ca2+) release channels that play a key role in Ca2+ signaling in cells. Three InsP(3)R isofonns-InsP(3)R type 1 (InsP(3)R1), InsP(3)R type 2 (InsP(3)R2), and InsP(3)R type 3 (InsP(3)R3) are expressed in mammals. A single InsP(3)R isoform is expressed in Drosophila melanogaster (DmInsP(3)R) and Caenorhabditis elegans (CeInsP(3)R). The progress made during last decade towards understanding the function and the properties of the InsP(3)R is briefly reviewed in this chapter. The main emphasis is on studies that revealed structural determinants responsible for the ligand recognition by the InsP(3)R, ion permeability of the InsP(3)R,modulation of the InsP(3)R by cytosolic Ca2+, ATP and PKA phosphorylation and on the recently identified InsP(3)R-binding partners. The main focus is on the InsP(3)R1, but the recent information about properties of other InsP(3)R isoforms is also discussed. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：261 / 272

页数：12

共 118 条

[1] Ca2+-calmodulin inhibits Ca2+ release mediated by type-1,-2 and-3 inositol trisphosphate receptors [J].

Adkins, CE ;

Morris, SA ;

De Smedt, H ;

Sienaert, I ;

Török, K ;

Taylor, CW .

BIOCHEMICAL JOURNAL, 2000, 345 :357-363

[2] Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Iβ [J].

Ammendola, A ;

Geiselhöringer, A ;

Hofmann, F ;

Schlossmann, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (26) :24153-24159

[3] IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor [J].

Ando, H ;

Mizutani, A ;

Matsu-ura, T ;

Mikoshiba, K .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (12) :10602-10612

[4] Caspase-3-induced truncation of type 1 inositol trisphosphate receptor accelerates apoptotic cell death and induces inositol trisphosphate-independent calcium release during apoptosis [J].

Assefa, Z ;

Bultynck, G ;

Szlufcik, K ;

Kasri, NN ;

Vermassen, E ;

Goris, J ;

Missiaen, L ;

Callewaert, G ;

Parys, JB ;

De Smedt, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (41) :43227-43236

[5] Loss of flight and associated neuronal rhythmicity in inositol 1,4,5-trisphosphate receptor mutants of Drosophila [J].

Banerjee, S ;

Lee, J ;

Venkatesh, K ;

Wu, CF ;

Hasan, G .

JOURNAL OF NEUROSCIENCE, 2004, 24 (36) :7869-7878

[6] Inositol 1,4,5-trisphosphate receptors are strongly expressed in the nervous system, pharynx, intestine, gonad and excretory cell of Caenorhabditis elegans and are encoded by a single gene (itr-1) [J].

Baylis, HA ;

Furuichi, T ;

Yoshikawa, F ;

Mikoshiba, K ;

Sattelle, DB .

JOURNAL OF MOLECULAR BIOLOGY, 1999, 294 (02) :467-476

[7]

BEZPROZVANNY I, 1995, J MEMBRANE BIOL, V145, P205

[8] Deranged neuronal calcium signaling and Huntington disease [J].

Bezprozvanny, I ;

Hayden, MR .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 322 (04) :1310-1317

[9] Direct association of ligand-binding and pore domains in homo- and heterotetrameric inositol 1,4,5-trisphosphate receptors [J].

Boehning, D ;

Joseph, SK .

EMBO JOURNAL, 2000, 19 (20) :5450-5459

[10] Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis [J].

Boehning, D ;

Patterson, RL ;

Sedaghat, L ;

Glebova, NO ;

Kurosaki, T ;

Snyder, SH .

NATURE CELL BIOLOGY, 2003, 5 (12) :1051-1061

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