Magnetic iron oxide nanoworms for tumor targeting and imaging

被引：473

作者：

Park, Ji-Ho ^{[1
]}

von Maltzahn, Geoffrey ^{[2
]}

Zhang, Lianglin ^{[3
]}

Schwartz, Michael P. ^{[1
]}

Ruoslahti, Erkki ^{[3
]}

Bhatia, Sangeeta N. ^{[2
]}

Sailor, Michael J. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, Mat Sci & Engn Program, La Jolla, CA 92093 USA

[2] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[3] Univ Calif Santa Barbara, Burnham Inst Med Res UCSB, Santa Barbara, CA 93106 USA

来源：

ADVANCED MATERIALS | 2008年 / 20卷 / 09期

关键词：

D O I：

10.1002/adma.200800004

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis, in vitro, and in vivo The particles consist of a chainlike aggregation of iron oxide (IO) cores in a dextran coating. When conjugated with a tumor-targeting peptide, they interact more effectively with a tumor-based target in vitro relative to spherical nanoparticles. Untargeted NW display similar in vivo circulation times and enhanced passive accumulation in mouse xenograft tumors relative to untargeted spherical IO nanoparticles.

引用

页码：1630 / +

页数：7

共 44 条

[1] Magnetite-loaded polymeric micelles as ultrasensitive magnetic-resonance probes [J].

Ai, H ;

Flask, C ;

Weinberg, B ;

Shuai, X ;

Pagel, MD ;

Farrell, D ;

Duerk, J ;

Gao, JM .

ADVANCED MATERIALS, 2005, 17 (16) :1949-+

[2] Nanocrystal targeting in vivo [J].

Åkerman, ME ;

Chan, WCW ;

Laakkonen, P ;

Bhatia, SN ;

Ruoslahti, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (20) :12617-12621

[3] Magnetic nanotube fabrication by using bacterial magnetic nanocrystals [J].

Banerjee, IA ;

Shima, LYM ;

Yoshino, T ;

Takeyama, H ;

Matsunaga, T ;

Matsui, H .

ADVANCED MATERIALS, 2005, 17 (09) :1128-+

[4] Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects [J].

Cai, WB ;

Shin, DW ;

Chen, K ;

Gheysens, O ;

Cao, QZ ;

Wang, SX ;

Gambhir, SS ;

Chen, XY .

NANO LETTERS, 2006, 6 (04) :669-676

[5] Role of target geometry in phagocytosis [J].

Champion, JA ;

Mitragotri, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (13) :4930-4934

[6] Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes [J].

Chithrani, B. Devika ;

Chan, Warren C. W. .

NANO LETTERS, 2007, 7 (06) :1542-1550

[7] Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells [J].

Chithrani, BD ;

Ghazani, AA ;

Chan, WCW .

NANO LETTERS, 2006, 6 (04) :662-668

[8] Nucleolin expressed at the cell surface is a marker of endothelial cells in angiogenic blood vessels [J].

Christian, S ;

Pilch, J ;

Akerman, ME ;

Porkka, K ;

Laakkonen, P ;

Ruoslahti, E .

JOURNAL OF CELL BIOLOGY, 2003, 163 (04) :871-878

[9] Divalent metal nanoparticles [J].

DeVries, Gretchen A. ;

Brunnbauer, Markus ;

Hu, Ying ;

Jackson, Alicia M. ;

Long, Brenda ;

Neltner, Brian T. ;

Uzun, Oktay ;

Wunsch, Benjamin H. ;

Stellacci, Francesco .

SCIENCE, 2007, 315 (5810) :358-361

[10] Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo [J].

Farokhzad, OC ;

Cheng, JJ ;

Teply, BA ;

Sherifi, I ;

Jon, S ;

Kantoff, PW ;

Richie, JP ;

Langer, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (16) :6315-6320

← 1 2 3 4 5 →