Contribution of interleukin 1β and KM loci to alopecia areata

被引:21
作者
Galbraith, GMP
Palesch, Y
Gore, EA
Pandey, JP
机构
[1] Med Univ S Carolina, Dept Microbiol & Immunol, Charleston, SC 29425 USA
[2] Med Univ S Carolina, Dept Dermatol, Charleston, SC 29425 USA
[3] Med Univ S Carolina, Dept Biometry, Charleston, SC 29425 USA
关键词
IL-1 beta polymorphisms; KM; alopecia areata;
D O I
10.1159/000022850
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Alopecia areata is a common skin disease in which proinflammatory cytokines such as IL-1 beta may play a pathogenic role. In this study, we examined the distribution of genotypes of an IL-1 beta single base change polymorphism at position +3953 in patients with alopecia areata, The distribution of immunoglobulin kappa light chain (KM) genotypes was similarly examined. The data obtained showed that the IL-1 beta and KM loci act cooperatively to significantly increase susceptibility to alopecia areata.
引用
收藏
页码:85 / 89
页数:5
相关论文
共 31 条
[1]  
Brinkman BMN, 1996, J INFLAMM, V46, P32
[2]  
COLOMBE BW, 1995, J AM ACAD DERMATOL, V33, P757
[3]   An analysis of linkage disequilibrium in the interleukin-1 gene cluster, using a novel grouping method for multiallelic markers [J].
Cox, A ;
Camp, NJ ;
Nicklin, MJH ;
di Giovine, FS ;
Duff, GW .
AMERICAN JOURNAL OF HUMAN GENETICS, 1998, 62 (05) :1180-1188
[4]   HLA-D LOCUS ASSOCIATIONS IN ALOPECIA-AREATA - DRW52A MAY CONFER DISEASE RESISTANCE [J].
DUVIC, M ;
HORDINSKY, MK ;
FIEDLER, VC ;
OBRIEN, WR ;
YOUNG, R ;
REVEILLE, JD .
ARCHIVES OF DERMATOLOGY, 1991, 127 (01) :64-68
[5]  
GALBRAITH GMP, 1989, AM J HUM GENET, V44, P426
[6]  
GALBRAITH GMP, 1984, CLIN EXP IMMUNOL, V56, P149
[7]  
GALBRAITH GMP, 1995, HUM GENET, V96, P433
[8]   Interleukin-1β+3953 allele 2:: association with disease status in adult periodontitis [J].
Gore, EA ;
Sanders, JJ ;
Pandey, JP ;
Palesch, Y ;
Galbraith, GMP .
JOURNAL OF CLINICAL PERIODONTOLOGY, 1998, 25 (10) :781-785
[9]   Interleukin-1 beta-induced inhibition of hair growth in vitro is mediated by cyclic AMP [J].
Hoffmann, R ;
Eicheler, W ;
Wenzel, E ;
Happle, R .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1997, 108 (01) :40-42
[10]   DOES INTERLEUKIN-1 INDUCE HAIR LOSS [J].
HOFFMANN, R ;
HAPPLE, R .
DERMATOLOGY, 1995, 191 (04) :273-275