Inhibition of sea urchin fertilization by fatty acid ethanolamides and cannabinoids

被引：22

作者：

Berdyshev, EV ^{[1
]}

机构：

[1] Inst Marine Biol, Vladivostok 690041, Russia

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1999年 / 122卷 / 03期

关键词：

anandamide; palmitoylethanolamide; fatty acid ethanolamides; tetrahydrocannabinol; WIN 55,212-2; SR; 141716; cannabinoids; fertilization; sea urchins;

D O I：

10.1016/S0742-8413(98)10136-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The influence of saturated and unsaturated fatty acid ethanolamides as well as Delta(9)-tetrahydrocannabinol (Delta(9)-THC), WIN 55,212-2 and cannabinoid CB1 receptor antagonist SR 141716 on sea urchin fertilization was studied. The ethanolamides of arachidonic, oleic and linoleic acids but not saturated fatty acid (C-14-C-20) derivatives inhibited fertilization when pre-incubated with sperm cells. Delta(9)-THC and WIN 55,212-2 also inhibited fertilization, Delta(9)-THC being ten times as potent as WIN 55,212-2. Selective cannabinoid CB1 receptor antagonist SR 141716 also blocked fertilization and did not antagonize the action of Delta(9)-THC. The obtained results indicate that different unsaturated fatty acid ethanolamides may control sea urchin fertilization, and that sea urchin sperm cell cannabinoid receptor may differ from the known cannabinoid receptor subtypes. (C) 1999 Elsevier Science Inc. All rights reserved.

引用

页码：327 / 330

页数：4

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