Inhibition of Src kinase activity by 7-[(2,4-dichloro-5-methoxyphenyl)-amino]-2-heteroaryl-thieno[3,2-b]pyridine-6-carbonitriles

被引：18

作者：

Boschelli, DH

Wu, BQ

Sosa, ACB

Chen, JJ

Golas, JM

Boschelli, F

机构：

[1] Wyeth Res, Chem & Screening Sci, Pearl River, NY 10965 USA

[2] Wyeth Res, Oncol, Pearl River, NY 10965 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 21期

关键词：

Src; thieno[3,2-b]pyridine-6-carbonitrile;

D O I：

10.1016/j.bmcl.2005.07.061

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

7-[(2,4-Dichloro-5-methoxyphenyl)aminolthieno[3,2-b]pyridine-6-carbonitriles with various heteroaryl groups at C-2 are inhibitors of Src kinase activity. Of these new analogs, compounds substituted at C-2 by a 3,5-furan or a 2,5-pyridine had the best activity in the Src enzyme and cell assays. (c) 2005 Elsevier Ltd. All rights reserved.

引用

收藏

页码：4681 / 4684

页数：4

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