Molecular detection of Parachlamydia-like organisms in cerebrospinal fluid of patients with multiple sclerosis

被引：9

作者：

Contini, C. ^{[1
]}

Seraceni, S.

Cultrera, R.

Castellazzi, M. ^{[2
]}

Granieri, E. ^{[2
]}

Fainardi, E. ^{[2
,3
]}

机构：

[1] Univ Ferrara, Fac Med, Infect Dis Sect, Dept Clin & Expt Med, I-44100 Ferrara, Italy

[2] Univ Ferrara, Neurol Sect, I-44100 Ferrara, Italy

[3] Azienda Osped Univ, Neuroradiol Unit, Ferrara, Italy

来源：

MULTIPLE SCLEROSIS JOURNAL | 2008年 / 14卷 / 04期

关键词：

Chlamydia-like organisms; cerebrospinal fluid; multiple sclerosis; polymerase chain reaction;

D O I：

10.1177/1352458507085796

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The presence of Chlamydia-like organism DNA was investigated by polymerase chain reaction (PCR) in cerebrospinal fluid (CSF) samples from 27 patients previously found positive for Chlamydia pneumoniae DNA: 12 with multiple sclerosis (MS), grouped according to clinical and magnetic resonance imaging (MRI) evidence of disease activity, 8 with other inflammatory neurological disorders and 7 with noninflammatory neurological disorders. PCR evidence of Chlamydia-like organisms in CSF was observed only in two relapsing-remitting MS patients with clinical and MRI disease activity. These findings suggest a possible association between C. pneumoniae and Chlamydia-like organism brain infections as a cofactor in MS development.

引用

页码：564 / 566

页数：3

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