Common sequence variants on 20q11.22 confer melanoma susceptibility

被引：163

作者：

Brown, Kevin M. ^{[2
]}

MacGregor, Stuart ^{[1
]}

Montgomery, Grant W. ^{[1
]}

Craig, David W. ^{[3
]}

Zhao, Zhen Zhen ^{[1
]}

Iyadurai, Kelly

Henders, Anjali K. ^{[1
]}

Homer, Nils ^{[4
]}

Campbell, Megan J. ^{[1
]}

Stark, Mitchell ^{[1
]}

Thomas, Shane ^{[1
]}

Schmid, Helen ^{[5
,6
]}

Holland, Elizabeth A. ^{[5
,6
]}

Gillanders, Elizabeth M. ^{[7
]}

Duffy, David L. ^{[1
]}

Maskiell, Judith A. ^{[8
]}

Jetann, Jodie ^{[9
]}

Ferguson, Megan ^{[9
]}

Stephan, Dietrich A. ^{[3
]}

Cust, Anne E. ^{[8
]}

Whiteman, David ^{[1
]}

Green, Adele ^{[1
]}

Olsson, Hakan ^{[10
]}

Puig, Susana ^{[11
]}

Ghiorzo, Paola ^{[12
]}

Hansson, Johan ^{[13
,14
]}

Demenais, Florence ^{[15
]}

Goldstein, Alisa M. ^{[16
]}

Gruis, Nelleke A. ^{[17
]}

Elder, David E. ^{[18
]}

Bishop, Julia Newton ^{[19
]}

Kefford, Richard F. ^{[5
,6
]}

Giles, Graham G. ^{[20
]}

Armstrong, Bruce K. ^{[21
]}

Aitken, Joanne F. ^{[9
]}

Hopper, John L. ^{[8
]}

Martin, Nicholas G. ^{[1
]}

Trent, Jeffrey M. ^{[22
]}

Mann, Graham J. ^{[5
,6
]}

Hayward, Nicholas K. ^{[1
]}

机构：

[1] Queensland Inst Med Res, Populat Studies & Genet Div, Brisbane, Qld 4029, Australia

[2] Translat Genom Res Inst, Integrated Canc Genom Div, Phoenix, AZ 85028 USA

[3] Translat Genom Res Inst, Neurogenom Div, Phoenix, AZ 85028 USA

[4] Univ Calif Los Angeles, Los Angeles, CA 90095 USA

[5] Univ Sydney, Westmead Millennium Inst, Sydney Melanoma Unit, Westmead, NSW 2145, Australia

[6] Univ Sydney, Westmead Inst Canc Res, Westmead, NSW 2145, Australia

[7] NHGRI, Inherited Dis Res Branch, Natl Inst Hlth, Baltimore, MD 21224 USA

[8] Univ Melbourne, Sch Populat Hlth, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic 3052, Australia

[9] Canc Council Queensland, Viertel Ctr Res Canc Control, Brisbane, Qld 4004, Australia

[10] Univ Hosp, Lund Canc Ctr, Dept Oncol, SE-22185 Lund, Sweden

[11] Univ Barcelona, Hosp Clin, Inst Invest Biomed August P & Sune, Dermatol Dept,Melanoma Unit, E-08036 Barcelona, Spain

[12] Univ Genoa, Dept Oncol Biol & Genet, I-16132 Genoa, Italy

[13] Karolinska Inst, Dept Oncol Pathol, S-17176 Stockholm, Sweden

[14] Karolinska Univ Hosp, S-17176 Stockholm, Sweden

[15] Fdn Jean Dausset CEPH, INSERM, U794, F-75010 Paris, France

[16] NCI, Div Canc Epidemiol & Genet, Genet Epidemiol Branch, Bethesda, MD 20892 USA

[17] Leiden Univ, Med Ctr, Dept Dermatol, NL-2333 AL Leiden, Netherlands

[18] Univ Pennsylvania, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[19] Univ Leeds, Leeds Inst Mol Med, Epidemiol & Biostat Sect, Leeds LS9 7TF, W Yorkshire, England

[20] Canc Council Victoria, Canc Epidemiol Ctr, Carlton, Vic 3053, Australia

[21] Univ Sydney, Sch Publ Hlth, Sydney, NSW 2006, Australia

[22] Translat Genom Res Inst, Genet Basis Human Dis Div, Phoenix, AZ 85028 USA

来源：

NATURE GENETICS | 2008年 / 40卷 / 07期

关键词：

D O I：

10.1038/ng.163

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10(-15)). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases.

引用

页码：838 / 840

页数：3

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