Emerging data on androgen receptor splice variants in prostate cancer

被引：53

作者：

Cao, Subing ^{[1
,2
]}

Zhan, Yang ^{[1
,2
]}

Dong, Yan ^{[1
,2
]}

机构：

[1] Jilin Univ, Coll Life Sci, Changchun, Jilin, Peoples R China

[2] Tulane Univ, Sch Med, Dept Struct & Cellular Biol, Tulane Canc Ctr, 1430 Tulane Ave, New Orleans, LA 70112 USA

来源：

基金：

中国国家自然科学基金;

关键词：

androgen receptor; splice variant; prostate cancer; dimerization; cofactors; DNA-BINDING DOMAIN; FULL-LENGTH; ABIRATERONE ACETATE; GENE-EXPRESSION; CELL-GROWTH; ENZALUTAMIDE RESISTANCE; INCREASED SURVIVAL; TARGET GENES; AR; AR-V7;

D O I：

10.1530/ERC-16-0298

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Androgen receptor splice variants are alternatively spliced variants of androgen receptor, which are C-terminally truncated and lack the canonical ligand-binding domain. Accumulating evidence has indicated a significant role of androgen receptor splice variants in mediating resistance of castration-resistant prostate cancer to current therapies and in predicting therapeutic responses. As such, there is an urgent need to target androgen receptor splicing variants for more effective treatment of castration-resistant prostate cancer. Identification of precise and critical targeting points to deactivate androgen receptor splicing variants relies on a deep understanding of how they are generated and the mechanisms of their action. In this review, we will focus on the emerging data on their generation, clinical significance and mechanisms of action as well as the therapeutic influence of these findings.

引用

页码：T199 / T210

页数：12

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