Normal Striatal Vesicular Acetylcholine Transporter Expression in Tourette Syndrome

被引：14

作者：

Albin, Roger L. ^{[1
,2
,3
,4
]}

Minderovic, Christine ^{[5
]}

Koeppe, Robert A. ^{[4
,5
]}

机构：

[1] Vet Affairs Ann Arbor Hlth Syst, Neurol Serv, Ann Arbor, MI 48105 USA

[2] Vet Affairs Ann Arbor Hlth Syst, Geriatr Res Educ & Clin Ctr, Ann Arbor, MI 48105 USA

[3] Univ Michigan, Dept Neurol, 5023 BSRB,109 Zina Pitcher Pl, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Morris K Udall Ctr, Ann Arbor, MI 41809 USA

[5] Univ Michigan, Dept Radiol, Ann Arbor, MI 48109 USA

来源：

ENEURO | 2017年 / 4卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Acetylcholine; Striatum; Tourette Syndrome; VChAT; CHOLINERGIC INTERNEURONS; GLUTAMATE-DECARBOXYLASE; BASAL GANGLIA; HALOPERIDOL; BRAIN; ACETYLTRANSFERASE; INDIVIDUALS; PARVALBUMIN; STABILITY; DOPAMINE;

D O I：

10.1523/ENEURO.0178-17.2017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Considerable prior work suggests basal ganglia dysfunction in Tourette syndrome (TS). Analysis of a small number of postmortem specimens suggests deficits of some striatal interneuron populations, including striatal cholinergic interneurons. To assess the integrity of striatal cholinergic interneurons in TS, we used [F-18] FEOBV positron emission tomography (PET) to quantify striatal vesicular acetylcholine transporter (VAChT) expression, a measure of cholinergic terminal density, in human TS and control subjects. We found no evidence of striatal cholinergic deficits. Discrepant imaging and postmortem analysis results may reflect agonal or postmortem changes, medication effects, or significant disease heterogeneity.

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页数：6

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