Chandrananimycins A-C:: Production of novel anticancer antibiotics from a marine Actinomadura sp isolate M048 by variation of medium composition and growth conditions

被引：99

作者：

Maskey, RP

Li, FRC

Qin, S

Fiebig, HH

Laatsch, H

机构：

[1] Univ Gottingen, Dept Organ Chem, D-37077 Gottingen, Germany

[2] Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China

[3] Oncotest GmbH, D-79108 Freiburg, Germany

来源：

JOURNAL OF ANTIBIOTICS | 2003年 / 56卷 / 07期

关键词：

D O I：

10.7164/antibiotics.56.622

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In our screening of marine actinomycetes for bioactive principles, three novel antibiotics designated as chandrananimycin A (3c), B (3d) and C (4) were isolated from the culture broth of a marine Actinomadura sp. isolate M045. The structures of the new antibiotics were determined by detailed interpretation of mass, 1 D and 2 D NMR spectra.

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页码：622 / 629

页数：8

相关论文

共 20 条

[1]

Biabani MAF, 1998, J ANTIBIOT, V51, P333

[2] C-13 NUCLEAR MAGNETIC-RESONANCE CHEMICAL-SHIFTS OF SUBSTITUTED PHENAZINES [J].

BREITMAIER, E ;

HOLLSTEIN, U .

JOURNAL OF ORGANIC CHEMISTRY, 1976, 41 (12) :2104-2108

[3]

Eggert C, 1997, MICROBIOL RES, V152, P315

[4]

GANGULY AK, 1970, CHEM IND-LONDON, P201

[5] THE C-13 NMR-SPECTRA AND ELECTRONIC-STRUCTURE OF 3H-PHENOXAZIN-3-ONES [J].

HASEGAWA, KI ;

UENO, Y .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1985, 58 (10) :2832-2839

[6] Glucosylquestiomycin, a novel antibiotic from Microbispora sp. TP-A0184:: Fermentation, isolation, structure determination, synthesis and biological activities [J].

Igarashi, Y ;

Takagi, K ;

Kajiura, T ;

Furumai, T ;

Oki, T .

JOURNAL OF ANTIBIOTICS, 1998, 51 (10) :915-920

[7] STUDIES ON CELL-GROWTH STIMULATING SUBSTANCES OF LOW-MOLECULAR-WEIGHT .2. EXFOLIAZONE AND LAVANDUCYANIN, POTENT GROWTH-PROMOTING SUBSTANCES OF RAT-LIVER CELL-LINE, RLN-8, PRODUCED BY STREPTOMYCES-EXFOLIATUS AND STREPTOMYCES-AERIOUVIFER [J].

IMAI, S ;

NOGUCHI, T ;

SETO, H .

JOURNAL OF ANTIBIOTICS, 1993, 46 (08) :1232-1238

[8] ISOLATION AND STRUCTURE OF A NEW PHENOXAZINE ANTIBIOTIC, EXFOLIAZONE, PRODUCED BY STREPTOMYCES-EXFOLIATUS [J].

IMAI, S ;

SHIMAZU, A ;

FURIHATA, K ;

FURIHATA, K ;

HAYAKAWA, Y ;

SETO, H .

JOURNAL OF ANTIBIOTICS, 1990, 43 (12) :1606-1607

[9]

KIM KB, 1999, HANGUK NONGHWA HAKHO, V42, P351

[10] STRUCTURES OF PHYTOTOXINS, AV-TOXINS-C, AV-TOXINS-D AND AV-TOXINS-E, PRODUCED BY ZONATE LEAF-SPOT FUNGUS OF MULBERRY [J].

KINJO, J ;

YOKOMIZO, K ;

AWATA, Y ;

SHIBATA, M ;

NOHARA, T ;

TERAMINE, T ;

TAKAHASHI, K .

TETRAHEDRON LETTERS, 1987, 28 (32) :3697-3698