Platinum(II) and palladium(II) complexes with 2-acetylpyridine thiosemicarbazone: cytogenetic and antineoplastic effects

被引：147

作者：

Iakovidou, Z

Papageorgiou, A

Demertzis, MA

Mioglou, E

Mourelatos, D ^{[1
]}

Kotsis, A

Yadav, PN

Kovala-Demertzi, D

机构：

[1] Aristotelian Univ Salonika, Fac Med, Lab Med Biol & Genet, GR-54006 Salonika, Greece

[2] Univ Ioannina, Dept Chem, GR-45110 Ioannina, Greece

[3] Theagen Anticanc Inst, Lab Expt Chemotherapy, Salonika, Greece

来源：

ANTI-CANCER DRUGS | 2001年 / 12卷 / 01期

关键词：

2-acetylpyridine thiosemicarbazone; antileukemic activity; cell kinetics; palladium(II); platinum(II); sister chromatid exchanges;

D O I：

10.1097/00001813-200101000-00009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effect of three novel complexes of Pt(II) and three complexes of Pd(II) with 2-acetylpyridine thiosemicarbazone (HAcTsc) on sister chromatid exchange (SCE) rates and human lymphocyte proliferation kinetics on a molar basis was studied. Also, the effect of Pt(II) and Pd(II) complexes against leukemia P388 was investigated. Among these compounds, the most effective in inducing antitumor and cytogenetic effects were the complexes [Pt(AcTsc)(2)].H2O and [Pd(AcTsc)(2)] while the rest, i.e. (HAcTsc), [Pt(AcTsc)CI], [Pt(HAcTsc)(2)]Cl-2. 2H(2)O, [Pd(AcTsc)Cl] and [Pd(HAcTsc)(2)]Cl-2, displayed marginal cytogenetic and antitumor effects. [(C) 2001 Lippincott Williams & Wilkins.].

引用

页码：65 / 70

页数：6

共 19 条

[1] DEEN DF, 1986, CANCER RES, V46, P1599
[2] Crystallization of an unstable molecular compound using a tailor-made additive
Domopoulou, A
Michaelides, A
Skoulika, S
Kovala-Demertzi, D
[J]. JOURNAL OF CRYSTAL GROWTH, 1998, 191 (1-2) : 166 - 168
[3] COMPARATIVE-STUDY ON SALMONELLA MUTAGENICITY AND ON CYTOGENETIC AND ANTINEOPLASTIC EFFECTS INDUCED BY CYCLOPHOSPHAMIDE AND 3-AMINOBENZAMIDE IN CELLS OF 3 TRANSPLANTABLE TUMORS IN-VIVO
ELIOPOULOS, P
MOURELATOS, D
DOZIVASSILIADES, J
[J]. MUTATION RESEARCH-GENETIC TOXICOLOGY, 1995, 342 (3-4): : 141 - 146
[4] CARCINOSTATIC ACTIVITY OF THIOSEMICARBAZONES OF FORMYL HETEROAROMATIC COMPOUNDS .6. 1-FORMYLISOQUINOLINE DERIVATIVES BEARING ADDITIONAL RING SUBSTITUENTS, WITH NOTES ON MECHANISM OF ACTION
FRENCH, FA
BLANZ, EJ
DOAMARAL, JR
FRENCH, DA
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1970, 13 (06) : 1117 - &
[5] GOLDIN A, 1980, CANC I MONGR, V55
[6] Palladium(II) and platinum(II) complexes of pyridine-2-carbaldehyde thiosemicarbazone with potential biological activity. Synthesis, structure and spectral properties. Extended network via hydrogen bond linkages of [Pd(PyTsc)Cl]
Kovala-Demertzi, D
Miller, JR
Kourkoumelis, N
Hadjikakou, SK
Demertzis, MA
[J]. POLYHEDRON, 1999, 18 (07) : 1005 - 1013
[7] Antineoplastic and cytogenetic effects of platinum(II) and palladium(II) complexes with pyridine-2-carboxyaldehyde-thiosemicarbazone
Kovala-Demertzi, D
Demertzis, MA
Varagi, V
Papageorgiou, A
Mourelatos, D
Mioglou, E
Iakovidou, Z
Kotsis, A
[J]. CHEMOTHERAPY, 1998, 44 (06) : 421 - 426
[8] Structures and spectral properties of palladium(II) complexes of 2-acetylpyridine N(4)-dimethylthiosemicarbazone
KovalaDemertzi, D
Domopoulou, A
Demertzis, MA
ValdesMartinez, J
HernandezOrtega, S
EspinosaPerez, G
West, DX
Salberg, MM
Bain, GA
Bloom, PD
[J]. POLYHEDRON, 1996, 15 (15) : 2587 - 2596
[9] COORDINATING PROPERTIES OF 2-ACETYLPYRIDINE THIOSEMICARBAZONE - PALLADIUM(II) COMPLEXES WITH NEUTRAL AND DEPROTONATED LIGAND - X-RAY STRUCTURE OF BROMO(2-ACETYLPYRIDINE THIOSEMICARBAZONATO) PALLADIUM(II)
KOVALADEMERTZI, D
DOMOPOULOU, A
DEMERTZIS, M
RAPTOPOULOU, CP
TERZIS, A
[J]. POLYHEDRON, 1994, 13 (12) : 1917 - 1925
[10] KRAKER A, 1985, J BIOL CHEM, V260, P3710

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