Association of MHC and rheumatoid arthritis HLA-DR4 and rheumatoid arthritis: studies in mice and men

被引：36

作者：

Fugger, L ^{[1
]}

Svejgaard, A

机构：

[1] Aarhus Univ Hosp, Skejby Sygehus, Dept Clin Immunol, DK-8200 Aarhus N, Denmark

[2] Copenhagen Univ Hosp, Rigshosp, Dept Clin Immunol, Copenhagen, Denmark

来源：

ARTHRITIS RESEARCH | 2000年 / 2卷 / 03期

关键词：

human leukocyte antigen; rheumatoid arthritis; transgenic mice;

D O I：

10.1186/ar89

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Inherited susceptibility to rheumatoid arthritis (RA) is asociated with the DRB1 genes encoding the human leukocyte antigen (HLA)-DR4 and HLA-DR1 molecules. Transgenic mice expressing these major histocompatibility complex (MHC) class II molecules have been developed to generate humanized models for RA. The relevance of these models for understanding RA will be discussed.

引用

页码：208 / U1

页数：5

共 34 条

[1] Definition of MHC and T cell receptor contacts in the HLA-DR4-restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice [J].

Andersson, EC ;

Hansen, BE ;

Jacobsen, H ;

Madsen, LS ;

Andersen, CB ;

Engberg, J ;

Rothbard, JB ;

McDevitt, GS ;

Malmström, V ;

Holmdahl, R ;

Svejgaard, A ;

Fugger, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (13) :7574-7579

[2]

Bläss S, 1999, ARTHRITIS RHEUM, V42, P2499, DOI 10.1002/1529-0131(199912)42:12<2499::AID-ANR1>3.0.CO

[3]

2-R

[4]

Cook AD, 1999, ARTHRITIS RHEUM, V42, P2569, DOI 10.1002/1529-0131(199912)42:12<2569::AID-ANR9>3.0.CO

[5]

2-3

[6]

de Vries N, 1999, ARTHRITIS RHEUM, V42, P1621, DOI 10.1002/1529-0131(199908)42:8<1621::AID-ANR9>3.0.CO

[7]

2-0

[8] X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II [J].

Dessen, A ;

Lawrence, CM ;

Cupo, S ;

Zaller, DM ;

Wiley, DC .

IMMUNITY, 1997, 7 (04) :473-481

[9]

Fox DA, 1997, ARTHRITIS RHEUM, V40, P598, DOI 10.1002/art.1780400403

[10] The HLA-DQ7 and -DQ8 associations in DR4-positive rheumatoid arthritis patients - A combined analysis of data available in the literature [J].

Fugger, L ;

Svejgaard, A .

TISSUE ANTIGENS, 1997, 50 (05) :494-500

← 1 2 3 4 →