cDNA cloning of a new low-density lipoprotein receptor-related protein and mapping of its gene (LRP3) to chromosome bands 19q12-q13.2

被引:39
作者
Ishii, H
Kim, DH
Fujita, T
Endo, Y
Saeki, S
Yamamoto, TT
机构
[1] Tohoku Univ, Ctr Gene Res, Aoba Ku, Sendai, Miyagi 9818555, Japan
[2] Fukushima Med Coll, Dept Biochem, Fukushima 96012, Japan
[3] Osaka City Univ, Dept Food & Nutr, Osaka 588, Japan
基金
日本学术振兴会;
关键词
D O I
10.1006/geno.1998.5339
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
We report herein the cDNA cloning of a novel member of the low-density lipoprotein receptor (LDLR) family termed LDLR-related protein 3 (LRP3). Human and rat LRP3 cDNAs encode a 770-amino-acid type 1 membrane protein with the following regions: a putative signal sequence, two isoleucine/leucine/valine-rich regions with an RGD sequence, two ligand-binding repeat regions, a putative transmembrane region, and a proline-rich cytoplasmic region with a tyrosine-based internalization signal. Fluorescence in situ hybridization of human chromosomes revealed that the human LRP3 gene mapped to chromosome bands 19q12-q13.2. LRP3 transcript was detected in a wide range of human tissues, with the highest expression in skeletal muscle and ovary. Despite the presence of the ligand-binding repeats, CHO cells transfected with LRP3 did not bind beta-migrating very-low-density lipoprotein or receptor-associated protein. (C) 1998 Academic Press.
引用
收藏
页码:132 / 135
页数:4
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