Variability in the 2′-5′-Oligoadenylate Synthetase Gene Cluster Is Associated with Human Predisposition to Tick-Borne Encephalitis Virus-Induced Disease

被引：63

作者：

Barkhash, Andrey V. ^{[1
,5
]}

Perelygin, Andrey A. ^{[1
]}

Babenko, Vladimir N. ^{[5
]}

Myasnikova, Natalia G. ^{[3
]}

Pilipenko, Pavel I. ^{[2
]}

Romaschenko, Aida G. ^{[5
]}

Voevoda, Mikhail I. ^{[4
,5
]}

Brinton, Margo A. ^{[1
]}

机构：

[1] Georgia State Univ, Dept Biol, Atlanta, GA 30302 USA

[2] Novosibirsk State Med Univ, Dept Clin Neurol & Algol, Novosibirsk, Russia

[3] Novosibirsk State Med Univ, Municipal Sci Pract Neurol Ctr, Novosibirsk, Russia

[4] Russian Acad Med Sci, Siberian Branch, Inst Internal Med, Novosibirsk, Russia

[5] Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Novosibirsk 630090, Russia

来源：

JOURNAL OF INFECTIOUS DISEASES | 2010年 / 202卷 / 12期

关键词：

FAMILY;

D O I：

10.1086/657418

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The 2'-5'-oligoadenylate synthetase (2'-5'-OAS) family members are interferon-induced antiviral proteins. Twenty-three single nucleotide polymorphisms located within the OAS1, OAS2, OAS3, and OASL genes were analyzed in 142 patients with Russian tick-borne encephalitis. Statistically significant differences in genotype, allele, and haplotype frequencies for 3 OAS2 single nucleotide polymorphisms (rs1293762, rs15895, and rs1732778) and 2 OAS3 single nucleotide polymorphisms (rs2285932 and rs2072136) were detected between patients with central nervous system disease and both those with fever and/or meningitis and the control group. The data suggest a possible association between these 5 OAS single nucleotide polymorphisms and the outcome of tick-borne encephalitis virus infection in a Russian population.

引用

页码：1813 / 1818

页数：6

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