Selective serotonin Reuptake inhibitors and risk of hemorrhagic stroke

被引：80

作者：

Kharofa, Jordan ^{[1
]}

Sekar, Padmini ^{[1
]}

Haverbusch, Mary ^{[1
]}

Moomaw, Charles ^{[1
]}

Flaherty, Matthew ^{[1
]}

Kissela, Brett ^{[1
]}

Broderick, Joseph ^{[1
]}

Woo, Daniel ^{[1
]}

机构：

[1] Univ Cincinnati, Dept Neurol, Cincinnati, OH 45267 USA

来源：

STROKE | 2007年 / 38卷 / 11期

关键词：

hemorrhage; SSRI; stroke;

D O I：

10.1161/STROKEAHA.107.491472

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose - Selective serotonin reuptake inhibitors ( SSRI) are widely prescribed. Several reports have observed an increased bleeding risk associated with SSRI use, which is hypothesized to be secondary to their antiplatelet effect. Methods - We tested the hypothesis that SSRIs increase the risk for or potentiate the risk of hemorrhagic stroke associated with antiplatelets and anticoagulants. Results - In multivariate analysis, we found no increased risk associated with SSRI use for intracerebral hemorrhage ( odds ratio = 1.1, 95% CI: 0.7 to 1.8; P = 0.63) or subarachnoid hemorrhage ( odds ratio = 0.6, 95% CI: 0.4 to 1.0; P = 0.054). In addition, potentiation of risk with warfarin or antiplatelets was not observed. Conclusions - Further studies with larger populations would be needed to exclude a small increase in intracranial hemorrhage risk with SSRI use.

引用

页码：3049 / 3051

页数：3

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