Design and pharmacology of quinuclidine derivatives as M2-selective muscarinic receptor ligands

被引：11

作者：

Böhme, TM

Keim, C

Dannhardt, G

Mutschler, E

Lambrecht, G

机构：

[1] Univ Mainz, Inst Pharm, D-55099 Mainz, Germany

[2] Univ Frankfurt, Bioctr Niederursel, Dept Pharmacol, D-60439 Frankfurt, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(01)00186-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In our search for M-2-selective muscarinic receptor antagonists, we synthesized 1,3-disubstituted indenes. The effects of different basic moieties with regard to binding and selectivity towards the five distinct muscarinic receptor subtypes were investigated. The results show that the quinuclidine series afforded the most promising compounds in terms of both receptor affinity and M-2-subtype selectivity. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：1241 / 1243

页数：3

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