Goigin tethers define subpopulations of COPI vesicles

被引：154

作者：

Malsam, J ^{[1
]}

Satoh, A ^{[1
]}

Pelletier, L ^{[1
]}

Warren, G ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Cell Biol, Ludwig Inst Canc Res, New Haven, CT 06520 USA

来源：

SCIENCE | 2005年 / 307卷 / 5712期

关键词：

D O I：

10.1126/science.1108061

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Coiled-coil proteins of the golgin family have been implicated in intra-Golgi transport through tethering coat protein complex I (COPI) vesicles. The p115-golgin tether is the best studied, and here we characterize the golgin-84-CASP tether. The vesicles bound by this tether were strikingly different from those bound by the p115-golgin tether in that they lacked members of the p24 family of putative cargo receptors and contained enzymes instead of anterograde cargo. Microinjected golgin-84 or CASP also inhibited Golgi-enzyme transport to the endoplasmic reticulum, further implicating this tether in retrograde transport. These and other golgins may modulate the flow patterns within the Golgi stack.

引用

页码：1095 / 1098

页数：4

共 28 条

[1] Rab1 recruitment of p115 into a cis-SNARE complex: Programming budding COPII vesicles for fusion [J].

Allan, BB ;

Moyer, BD ;

Balch, WE .

SCIENCE, 2000, 289 (5478) :444-448

[2] Rapid, endoplasmic reticulum-independent diffusion of the mitotic golgi haze [J].

Axelsson, MAB ;

Warren, G .

MOLECULAR BIOLOGY OF THE CELL, 2004, 15 (04) :1843-1852

[3] The coiled-coil membrane protein golgin-84 is a novel rab effector required for Golgi ribbon formation [J].

Diao, A ;

Rahman, D ;

Pappin, DJC ;

Lucocq, J ;

Lowe, M .

JOURNAL OF CELL BIOLOGY, 2003, 160 (02) :201-212

[4] gp25L/emp24/p24 protein family members of the cis-Golgi network bind both COP I and II coatomer [J].

Dominguez, M ;

Dejgaard, K ;

Füllekrug, J ;

Dahan, S ;

Fazel, A ;

Paccaud, JP ;

Thomas, DY ;

Bergeron, JJM ;

Nilsson, T .

JOURNAL OF CELL BIOLOGY, 1998, 140 (04) :751-765

[5] Long coiled-coil proteins and membrane traffic [J].

Gillingham, AK ;

Munro, S .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2003, 1641 (2-3) :71-85

[6] CASP, the alternatively spliced product of the gene encoding the CCAAT-displacement protein transcription factor, is a Golgi membrane protein related to giantin [J].

Gillingham, AK ;

Pfeifer, AC ;

Munro, S .

MOLECULAR BIOLOGY OF THE CELL, 2002, 13 (11) :3761-3774

[7] Evidence for a COP-I-independent transport route from the Golgi complex to the endoplasmic reticulum [J].

Girod, A ;

Storrie, B ;

Simpson, JC ;

Johannes, L ;

Goud, B ;

Roberts, LM ;

Lord, JM ;

Nilsson, T ;

Pepperkok, R .

NATURE CELL BIOLOGY, 1999, 1 (07) :423-430

[8] The curious status of the Golgi apparatus [J].

Glick, BS ;

Malhotra, V .

CELL, 1998, 95 (07) :883-889

[9] TARGETING OF PROTEIN ERGIC-53 TO THE ER/ERGIC/CIS-GOLGI RECYCLING PATHWAY [J].

ITIN, C ;

SCHINDLER, R ;

HAURI, HP .

JOURNAL OF CELL BIOLOGY, 1995, 131 (01) :57-67

[10] Sorting of Golgi resident proteins into different subpopulations of COPI vesicles: a role for ArfGAP1 [J].

Lanoix, J ;

Ouwendijk, J ;

Stark, A ;

Szafer, S ;

Cassel, D ;

Dejgaard, K ;

Weiss, M ;

Nilsson, T .

JOURNAL OF CELL BIOLOGY, 2001, 155 (07) :1199-1212

← 1 2 3 →