Ytterbium triflate-promoted tandem one-pot oxidation-Cannizzaro reaction of aryl methyl ketones

被引：44

作者：

Curini, M ^{[1
]}

Epifano, F ^{[1
]}

Genovese, S ^{[1
]}

Marcotullio, MC ^{[1
]}

Rosati, O ^{[1
]}

机构：

[1] Dipartimento Chim & Tecnol Farmaco, Sezione Chim Organ, I-06123 Perugia, Italy

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 07期

关键词：

D O I：

10.1021/ol050125e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ytterbium triflate was shown to be an effective catalyst in promoting the synthesis of either isopropyl esters or free alpha-hydroxy-arylacetic acids from substituted aromatic glyoxals and aryl methyl ketones, respectively. The reaction to provide acids starting from differently substituted ketones was carried out by an environmentally friendly method using an aqueous medium as a solvent and giving the adducts in 78-99% yield without any further purification after the usual workup.

引用

页码：1331 / 1333

页数：3

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