Derivation and differentiation of glomerular endothelial cells

被引：13

作者：

Abrahamson, DR ^{[1
]}

Robert, B ^{[1
]}

机构：

[1] Univ Kansas, Med Ctr, Dept Cell Biol & Anat, Kansas City, KS 66160 USA

来源：

NEPHROLOGY DIALYSIS TRANSPLANTATION | 2003年 / 18卷

关键词：

angiogenesis; differentiation; endothelial cells; Flk1; glomerulus; neuropilin-1; vasculogenesis; VEGF; GROWTH-FACTOR; ORIGIN; NEUROPILIN-1; RECEPTOR; GRAFTS; FLK1;

D O I：

10.1093/ndt/gfg1056

中图分类号：

R3 [基础医学]; R4 [临床医学];

学科分类号：

1001 ; 1002 ; 100602 ;

摘要：

Data on the embryonic derivation of metanephric endothelial cells are reviewed, paying particular attention to results obtained from anterior chamber and intrarenal grafts of embryonic kidneys. Most of the evidence supports an intrinsic origin of the endothelium, which probably differentiates from metanephric mesenchyme. The roles of several growth factor receptor/ligand systems are also discussed, with an emphasis on the VEGF receptors, Flk1 and neuropilin- 1.

引用

页码：2 / 7

页数：6

共 23 条

[1]

ABRAHAMSON DR, 1991, LAB INVEST, V64, P629

[2] Endothelial signal integration in vascular assembly [J].

Daniel, TO ;

Abrahamson, D .

ANNUAL REVIEW OF PHYSIOLOGY, 2000, 62 :649-671

[3]

Daniel TO, 1996, KIDNEY INT, V50, pS73

[4] THE ORIGIN OF THE GLOMERULAR ENDOTHELIUM [J].

EKBLOM, P ;

SARIOLA, H ;

KARKINENJAASKELAINEN, M ;

SAXEN, L .

CELL DIFFERENTIATION, 1982, 11 (01) :35-39

[5] Role of vascular endothelial growth factor in the regulation of angiogenesis [J].

Ferrara, N .

KIDNEY INTERNATIONAL, 1999, 56 (03) :794-814

[6] Receptors for collapsin/semaphorins [J].

Fujisawa, H ;

Kitsukawa, T .

CURRENT OPINION IN NEUROBIOLOGY, 1998, 8 (05) :587-592

[7] Surface densities of ephrin-B1 determine EphB1-coupled activation of cell attachment through αvβ3 and α5β1 integrins [J].

Huynh-Do, U ;

Stein, E ;

Lane, AA ;

Liu, H ;

Cerretti, DP ;

Daniel, TO .

EMBO JOURNAL, 1999, 18 (08) :2165-2173

[8]

HYINK DP, 1995, SEMIN NEPHROL, V15, P300

[9] Endogenous origin of glomerular endothelial and mesangial cells in grafts of embryonic kidneys [J].

Hyink, DP ;

Tucker, DC ;

StJohn, PL ;

Leardkamolkarn, V ;

Accavitti, MA ;

Abrass, CK ;

Abrahamson, DR .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 1996, 270 (05) :F886-F899

[10]

Kawasaki T, 1999, DEVELOPMENT, V126, P4895

← 1 2 3 →