Synthesis of (2S,3S)-β-methyltryptophan

被引：29

作者：

Han, GX ^{[1
]}

Lewis, A ^{[1
]}

Hruby, VJ ^{[1
]}

机构：

[1] Univ Arizona, Dept Chem, Tucson, AZ 85721 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 28期

关键词：

constrained amino acids; auxiliary assisted asymmetric synthesis; beta-methyltryptophan; lithium bromide (LiBr); N; N-dimethyl-aminopyridine; (DMAP);

D O I：

10.1016/S0040-4039(01)00718-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-alpha-Fmoc-prptected (1S,3S)-beta -methyltryptophan has been synthesized by asymmetric synthesis through the aid of an oxazolidinone auxillary. Coupling of the mixed anhydride of N-ln-Boc-protected indoleacrylic acid to thr oxazolidinone auxiliary was achieved by lithium bromide and N,N-dimethylpyridine (DMAP). This reaction is milder and more convenient to run than the traditional conditions using: butyl lithium, (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：4601 / 4603

页数：3

共 11 条

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