Premature ejaculation associated with citalopram withdrawal

被引:37
作者
Adson, DE
Kotlyar, M
机构
[1] Univ Minnesota, Sch Med, Dept Psychiat, Fairview Univ Med Ctr, Minneapolis, MN 55454 USA
[2] Univ Minnesota, Coll Pharm, Dept Expt & Clin Pharmacol, Minneapolis, MN 55455 USA
关键词
citalopram; premature ejaculation; withdrawal syndrome;
D O I
10.1345/aph.1D214
中图分类号
R9 [药学];
学科分类号
1007 [药学];
摘要
OBJECTIVE: To report a case of premature ejaculation occurring subsequent to citalopram discontinuation. CASE SUMMARY: A 43-year-old white man being treated for depression with citalopram wished to discontinue treatment. Four or 5 days after stopping citalopram he reported that, during sexual intercourse, his genitals seemed to be extremely sensitive and orgasm was achieved within approximately 1 minute. These symptoms continued over the next 3-4 weeks and remitted after citalopram was restarted. Several subsequent attempts to discontinue citalopram resulted in a return of these symptoms despite using a slow tapering regimen. An objective causality assessment revealed a probable relationship between drug withdrawal and the observed symptoms. DISCUSSION: The ability of selective serotonin-reuptake inhibitors (SSRls) to delay ejaculation has been well documented; however, discontinuation of these agents generally results in a return to baseline function. Although discontinuation of SSRI therapy has been associated with a number of withdrawal symptoms, this is the first report (MEDLINE, September 2003), to our knowledge, of the emergence of sexual adverse effects in someone with no previous history of these symptoms. CONCLUSIONS: Premature ejaculation is a possible withdrawal effect after SSRI discontinuation. Since patients are usually reluctant to spontaneously report sexual adverse effects, it is important to specifically inquire about them both when starting and stopping treatment with an SSRI.
引用
收藏
页码:1804 / 1806
页数:3
相关论文
共 15 条
[1]
ALTHOF SE, 1995, J CLIN PSYCHIAT, V56, P402
[2]
Gelenberg AJ, 2000, J CLIN PSYCHIAT, V61, P681
[3]
Antidepressant-induced sexual dysfunction [J].
Gregorian, RS ;
Golden, KA ;
Bahce, A ;
Goodman, C ;
Kwong, WJ ;
Khan, ZM .
ANNALS OF PHARMACOTHERAPY, 2002, 36 (10) :1577-1589
[4]
Pharmacokinetics of selective serotonin reuptake inhibitors [J].
Hiemke, C ;
Härtter, S .
PHARMACOLOGY & THERAPEUTICS, 2000, 85 (01) :11-28
[5]
An assessment of selective serotonin reuptake inhibitor discontinuation symptoms with citalopram [J].
Markowitz, JS ;
DeVane, CL ;
Liston, HL ;
Montgomery, SA .
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 2000, 15 (06) :329-333
[6]
McMahon C G, 1999, Curr Opin Urol, V9, P553, DOI 10.1097/00042307-199911000-00011
[7]
Treatment of premature ejaculation with sertraline hydrochloride: A single-blind placebo controlled crossover study [J].
McMahon, CG .
JOURNAL OF UROLOGY, 1998, 159 (06) :1935-1938
[8]
The neurobiology of sexual function [J].
Meston, CM ;
Frohlich, PF .
ARCHIVES OF GENERAL PSYCHIATRY, 2000, 57 (11) :1012-1030
[9]
Montejo AL, 2001, J CLIN PSYCHIAT, V62, P10
[10]
A METHOD FOR ESTIMATING THE PROBABILITY OF ADVERSE DRUG-REACTIONS [J].
NARANJO, CA ;
BUSTO, U ;
SELLERS, EM ;
SANDOR, P ;
RUIZ, I ;
ROBERTS, EA ;
JANECEK, E ;
DOMECQ, C ;
GREENBLATT, DJ .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1981, 30 (02) :239-245