Cell-SELEX: Novel perspectives of aptamer-based therapeutics

被引：122

作者：

Guo, Ke-Tai ^{[1
]}

Paul, Angela ^{[1
]}

Schichor, Christian ^{[2
]}

Ziemer, Gerhard ^{[1
]}

Wendel, Hans P. ^{[1
]}

机构：

[1] Univ Tubingen Hosp, Dept Thorac Cardiac & Vasc Surg, D-72076 Tubingen, Germany

[2] Univ Munich, Klinikum Grosshadern, Dept Neurosurg, D-81377 Munich, Germany

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2008年 / 9卷 / 04期

关键词：

cell-SELEX; aptamer; nanotechnology;

D O I：

10.3390/ijms9040668

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aptamers, single stranded DNA or RNA molecules, generated by a method called SELEX (systematic evolution of ligands by exponential enrichment) have been widely used in various biomedical applications. The newly developed Cell-SELEX (cell based-SELEX) targeting whole living cells has raised great expectations for cancer biology, -therapy and regenerative medicine. Combining nanobiotechnology with aptamers, this technology opens the way to more sophisticated applications in molecular diagnosis. This paper gives a review of recent developments in SELEX technologies and new applications of aptamers.

引用

页码：668 / 678

页数：11

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