The E. Donnall Thomas lecture - Manipulating and visualizing T-cell alloresponses

被引：1

作者：

Blazar, BR ^{[1
]}

机构：

[1] Univ Minnesota, Ctr Canc, Dept Pediat, Minneapolis, MN 55455 USA

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2005年 / 11卷 / 09期

关键词：

graft-versus-host disease; alloengraftment; alloresponses; imaging T-cell tracking;

D O I：

10.1016/j.bbmt.2005.07.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In summary, blockade of the costimulatory CD28/B7 pathway inhibits, but does not eliminate GVHD. Blockade of the coinhibitory CTLA4/B7 pathway accelerates GVHD. The incomplete efficacy of blocking the CD28/B7 pathway suggested that other pathways may be contributing to the generation of a productive immune response culminating in GVHD lethality. © 2005 American Society for Blood and Marrow Transplantation.

引用

页码：651 / 656

页数：6