Production of methyl 3-oxoartemisinate from methyl artemisinate by suspension cell culture of Mentha piperita

被引：3

作者：

Kim, S ^{[1
]}

Kwon, H ^{[1
]}

机构：

[1] SEOUL NATL UNIV, COLL AGR & LIFE SCI, NEW BIOMAT AGR RES CTR, SUWON 441744, SOUTH KOREA

来源：

PLANTA MEDICA | 1996年 / 62卷 / 04期

关键词：

D O I：

10.1055/s-2006-957904

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Methyl artemisinate was fed to the suspension cell culture of Mentha piperita. The biotransformation product was isolated and identified as a novel compound, methyl 3-oxo-artemisinate. The Mentha cells were apparently capable of extensively oxidizing at the allylic C-3 position, to give rise to an oxo group. The conversion of the fed methyl ester of the acid reached a maximum in 48 h with 5.5% conversion. The physicochemical data of the oxo compound are presented.

引用

页码：359 / 360

页数：2

共 16 条

[1] SYNTHESIS AND ANTIMALARIAL ACTIVITY OF SOME 9-SUBSTITUTED ARTEMISININ DERIVATIVES [J].

ACTON, N ;

KARLE, JM ;

MILLER, RE .

JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (17) :2552-2557

[2] SECONDARY METABOLISM IN PLANT-TISSUE CULTURE - SCOPE AND LIMITATIONS [J].

BANTHORPE, DV .

NATURAL PRODUCT REPORTS, 1994, 11 (03) :303-328

[3] THE APPLICATION OF VACUUM LIQUID-CHROMATOGRAPHY TO THE SEPARATION OF TERPENE MIXTURES [J].

COLL, JC ;

BOWDEN, BF .

JOURNAL OF NATURAL PRODUCTS, 1986, 49 (05) :934-936

[4] ON THE POSSIBLE ROLE OF QUINGHAO ACID IN THE BIOSYNTHESIS OF ARTEMISININ [J].

ELFERALY, FS ;

ALMESHAL, IA ;

ALYAHYA, MA ;

HIFNAWY, MS .

PHYTOCHEMISTRY, 1986, 25 (12) :2777-2778

[5] MICROBIOLOGICAL TRANSFORMATIONS OF ARTEMISINIC ACID [J].

ELMARAKBY, SA ;

ELFERALY, FS ;

ELSOHLY, HN ;

CROOM, EM ;

HUFFORD, CD .

PHYTOCHEMISTRY, 1988, 27 (10) :3089-3091

[6]

Fieser LF, 1967, REAGENTS ORGANIC SYN, V1, P191

[7] CATALYZED OXYGENATION OF ALLYLIC HYDROPEROXIDES DERIVED FROM QINGHAO (ARTEMISINIC) ACID - CONVERSION OF QINGHAO ACID INTO DEHYDROQINGHAOSU (ARTEMISITENE) AND QINGHAOSU (ARTEMISININ) [J].

HAYNES, RK ;

VONWILLER, SC .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1990, (06) :451-453

[8] PREPARATION OF A CYCLOPROPANE-CONTAINING ANALOG OF ARTEMISININ [J].

KIM, SU ;

CHOI, JH ;

KIM, SS .

JOURNAL OF NATURAL PRODUCTS, 1993, 56 (06) :857-863

[9] QINGHAOSU (ARTEMISININ) - AN ANTIMALARIAL DRUG FROM CHINA [J].

KLAYMAN, DL .

SCIENCE, 1985, 228 (4703) :1049-1055

[10] PRODUCTION OF (-)-7-HYDROXYISOPIPERITENONE FROM (-)-ISOPIPERITENONE BY A SUSPENSION CELL-CULTURE OF MENTHA-PIPERITA [J].

PARK, SH ;

CHAE, YA ;

LEE, HJ ;

LIM, YH ;

KIM, SU .

PLANTA MEDICA, 1994, 60 (04) :374-375

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