GABAergic mechanisms in the action of general anesthetics

被引：25

作者：

Hirota, K

Roth, SH

Fujimura, J

Masuda, A

Ito, Y

机构：

[1] Toyama Med & Pharmaceut Univ, Sch Med, Dept Anesthesiol, Sugitani, Toyama 93001, Japan

[2] Univ Calgary, Dept Pharmacol & Therapeut, Calgary, AB T2N 4N1, Canada

[3] Univ Calgary, Fac Med, Dept Anaesthesia, Calgary, AB T2N 4N1, Canada

来源：

TOXICOLOGY LETTERS | 1998年 / 101卷

关键词：

agent specific action; general anesthetics; population spike; rat hippocampal slice;

D O I：

10.1016/S0378-4274(98)00186-6

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

1. The effects of volatile and intravenous anesthetics were studied on evoked field potentials in rat hippocampal CA1 neurons in vitro to determine the role of GABAergic mechanisms in the action of general anesthetics. 2. It was observed that both volatile (halothane, isoflurane, sevoflurane) and intravenous (thiopental, pentobarbital, propofol) anesthetics decreased population spike (PS) amplitudes. 3. Using paired-pulse paradigms, it was revealed that volatile agents enhance paired-pulse facilitation (PPF), and intravenous agents reduce PPF. Use-dependent effects on PS amplitudes were observed following application of the intravenous anesthetics, whereas volatile agents did not show use-dependency. The effects of the intravenous anesthetics were blocked by the GABA(A) receptor antagonist, bicuculline. 4. It is suggested that agent specific actions of general anesthetics are a result of differential effects on GABAergic mechanisms that modulate synaptic transmission. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：203 / 207

页数：5

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