A role for stem cell biology in the physiological and pathological aspects of aging

被引：24

作者：

Snyder, EY ^{[1
]}

Loring, JE ^{[1
]}

机构：

[1] Burnham Inst, La Jolla, CA 92037 USA

来源：

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY | 2005年 / 53卷 / 09期

关键词：

transplantation; human stem cells; plasticity; neurodegenerative disease; stroke;

D O I：

10.1111/j.1532-5415.2005.53491.x

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The stem cell is an essential component of a developmental phenomenon-one of the key components of a program fundamental to organogenesis and the maintenance of homeostasis throughout life. The stem cell confers plasticity to the process. Because aging is part of the developmental arc, an understanding of the stem cell is essential to understanding aging and some of the degenerative conditions that accompany it. Because stem cells may be isolated and manipulated ex vivo and then reimplanted into organs, they may serve a variety of functions. They have the capability of migrating long distances and targeting pathological conditions, of expressing therapeutic genes and responding to cues that shift their differentiation toward deficient lineages. Therefore, stem cells may be used for cell replacement, for therapeutic interventions, and potentially to modify aging.

引用

收藏

页码：S287 / S291

页数：5

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