Delineating the genetic basis of systemic lupus erythematosus

被引：471

作者：

Wakeland, EK

Liu, K

Graham, RR

Behrens, TW

机构：

[1] Univ Minnesota, Sch Med, Dept Med, Ctr Immunol, Minneapolis, MN 55455 USA

[2] Univ Texas, SW Med Ctr, Ctr Immunol, Dallas, TX 75235 USA

来源：

IMMUNITY | 2001年 / 15卷 / 03期

关键词：

D O I：

10.1016/S1074-7613(01)00201-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Genetic predisposition plays a crucial role in susceptibility to systemic lupus erythematosus (SLE) in both human patients and animal models. Recent progress in experimental systems and human linkage analysis is providing key insights into the genetic basis for susceptibility and elucidating the manner in which genetic interactions mediate severe disease pathogenesis. Genes in multiple pathways appear to participate in specific elements of the disease, and epistatic interactions among these genes play an important role in both aggravating and suppressing disease development.

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收藏

页码：397 / 408

页数：12

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