共 12 条
The importance of applying toxicogenomics to increase the efficiency of drug discovery
被引:4
作者:

Barros, SA
论文数: 0 引用数: 0
h-index: 0
机构:
Millennium Pharmaceut Inc, Drug Safety & Disposit, Cambridge, MA 02139 USA Millennium Pharmaceut Inc, Drug Safety & Disposit, Cambridge, MA 02139 USA
机构:
[1] Millennium Pharmaceut Inc, Drug Safety & Disposit, Cambridge, MA 02139 USA
关键词:
D O I:
10.2217/14622416.6.6.547
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
引用
收藏
页码:547 / 550
页数:4
相关论文
共 12 条
[1]
Toxicogenomics-based discrimination of toxic mechanism in HepG2 human hepatoma cells
[J].
Burczynski, ME
;
McMillian, M
;
Ciervo, J
;
Li, L
;
Parker, JB
;
Dunn, RT
;
Hicken, S
;
Farr, S
;
Johnson, MD
.
TOXICOLOGICAL SCIENCES,
2000, 58 (02)
:399-415

Burczynski, ME
论文数: 0 引用数: 0
h-index: 0
机构: Robert Wood Johnson Pharmaceut Res Inst, Drug Safety Evaluat, Raritan, NJ 08869 USA

McMillian, M
论文数: 0 引用数: 0
h-index: 0
机构: Robert Wood Johnson Pharmaceut Res Inst, Drug Safety Evaluat, Raritan, NJ 08869 USA

Ciervo, J
论文数: 0 引用数: 0
h-index: 0
机构: Robert Wood Johnson Pharmaceut Res Inst, Drug Safety Evaluat, Raritan, NJ 08869 USA

Li, L
论文数: 0 引用数: 0
h-index: 0
机构: Robert Wood Johnson Pharmaceut Res Inst, Drug Safety Evaluat, Raritan, NJ 08869 USA

Parker, JB
论文数: 0 引用数: 0
h-index: 0
机构: Robert Wood Johnson Pharmaceut Res Inst, Drug Safety Evaluat, Raritan, NJ 08869 USA

Dunn, RT
论文数: 0 引用数: 0
h-index: 0
机构: Robert Wood Johnson Pharmaceut Res Inst, Drug Safety Evaluat, Raritan, NJ 08869 USA

Hicken, S
论文数: 0 引用数: 0
h-index: 0
机构: Robert Wood Johnson Pharmaceut Res Inst, Drug Safety Evaluat, Raritan, NJ 08869 USA

Farr, S
论文数: 0 引用数: 0
h-index: 0
机构: Robert Wood Johnson Pharmaceut Res Inst, Drug Safety Evaluat, Raritan, NJ 08869 USA

Johnson, MD
论文数: 0 引用数: 0
h-index: 0
机构: Robert Wood Johnson Pharmaceut Res Inst, Drug Safety Evaluat, Raritan, NJ 08869 USA
[2]
New technologies and screening strategies for hepatotoxicity: Use of in vitro models
[J].
Dambach, DM
;
Andrews, BA
;
Moulin, F
.
TOXICOLOGIC PATHOLOGY,
2005, 33 (01)
:17-26

Dambach, DM
论文数: 0 引用数: 0
h-index: 0
机构:
Bristol Myers Squibb Co, Discovery Toxicol, Pharmaceut Res Inst, Princeton, NJ 08543 USA Bristol Myers Squibb Co, Discovery Toxicol, Pharmaceut Res Inst, Princeton, NJ 08543 USA

Andrews, BA
论文数: 0 引用数: 0
h-index: 0
机构:
Bristol Myers Squibb Co, Discovery Toxicol, Pharmaceut Res Inst, Princeton, NJ 08543 USA Bristol Myers Squibb Co, Discovery Toxicol, Pharmaceut Res Inst, Princeton, NJ 08543 USA

Moulin, F
论文数: 0 引用数: 0
h-index: 0
机构:
Bristol Myers Squibb Co, Discovery Toxicol, Pharmaceut Res Inst, Princeton, NJ 08543 USA Bristol Myers Squibb Co, Discovery Toxicol, Pharmaceut Res Inst, Princeton, NJ 08543 USA
[3]
The price of innovation: new estimates of drug development costs
[J].
DiMasi, JA
;
Hansen, RW
;
Grabowski, HG
.
JOURNAL OF HEALTH ECONOMICS,
2003, 22 (02)
:151-185

DiMasi, JA
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, Tufts Ctr Study Drug Dev, Boston, MA 02111 USA

Hansen, RW
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, Tufts Ctr Study Drug Dev, Boston, MA 02111 USA

Grabowski, HG
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, Tufts Ctr Study Drug Dev, Boston, MA 02111 USA
[4]
The value of improving the productivity of the drug development process - Faster times and better decisions
[J].
DiMasi, JA
.
PHARMACOECONOMICS,
2002, 20 (Suppl 3)
:1-10

DiMasi, JA
论文数: 0 引用数: 0
h-index: 0
机构:
Tufts Univ, Ctr Study Drug Dev, Boston, MA 02111 USA Tufts Univ, Ctr Study Drug Dev, Boston, MA 02111 USA
[5]
Comparison of the expression profiles induced by genotoxic and nongenotoxic carcinogens in rat liver
[J].
Ellinger-Ziegelbauer, H
;
Stuart, B
;
Wahle, B
;
Bomann, W
;
Ahr, HJ
.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS,
2005, 575 (1-2)
:61-84

Ellinger-Ziegelbauer, H
论文数: 0 引用数: 0
h-index: 0
机构: Bayer HealthCare, Dept Mol & Genet Toxicol, D-42096 Wuppertal, Germany

Stuart, B
论文数: 0 引用数: 0
h-index: 0
机构: Bayer HealthCare, Dept Mol & Genet Toxicol, D-42096 Wuppertal, Germany

Wahle, B
论文数: 0 引用数: 0
h-index: 0
机构: Bayer HealthCare, Dept Mol & Genet Toxicol, D-42096 Wuppertal, Germany

Bomann, W
论文数: 0 引用数: 0
h-index: 0
机构: Bayer HealthCare, Dept Mol & Genet Toxicol, D-42096 Wuppertal, Germany

Ahr, HJ
论文数: 0 引用数: 0
h-index: 0
机构: Bayer HealthCare, Dept Mol & Genet Toxicol, D-42096 Wuppertal, Germany
[6]
Prediction of compound signature using high density gene expression profiling
[J].
Hamadeh, HK
;
Bushel, PR
;
Jayadev, S
;
DiSorbo, O
;
Bennett, L
;
Li, LP
;
Tennant, R
;
Stoll, R
;
Barrett, JC
;
Paules, RS
;
Blanchard, K
;
Afshari, CA
.
TOXICOLOGICAL SCIENCES,
2002, 67 (02)
:232-240

Hamadeh, HK
论文数: 0 引用数: 0
h-index: 0
机构: NIEHS, Res Triangle Pk, NC 27709 USA

Bushel, PR
论文数: 0 引用数: 0
h-index: 0
机构: NIEHS, Res Triangle Pk, NC 27709 USA

Jayadev, S
论文数: 0 引用数: 0
h-index: 0
机构: NIEHS, Res Triangle Pk, NC 27709 USA

DiSorbo, O
论文数: 0 引用数: 0
h-index: 0
机构: NIEHS, Res Triangle Pk, NC 27709 USA

Bennett, L
论文数: 0 引用数: 0
h-index: 0
机构: NIEHS, Res Triangle Pk, NC 27709 USA

Li, LP
论文数: 0 引用数: 0
h-index: 0
机构: NIEHS, Res Triangle Pk, NC 27709 USA

Tennant, R
论文数: 0 引用数: 0
h-index: 0
机构: NIEHS, Res Triangle Pk, NC 27709 USA

Stoll, R
论文数: 0 引用数: 0
h-index: 0
机构: NIEHS, Res Triangle Pk, NC 27709 USA

Barrett, JC
论文数: 0 引用数: 0
h-index: 0
机构: NIEHS, Res Triangle Pk, NC 27709 USA

Paules, RS
论文数: 0 引用数: 0
h-index: 0
机构: NIEHS, Res Triangle Pk, NC 27709 USA

Blanchard, K
论文数: 0 引用数: 0
h-index: 0
机构: NIEHS, Res Triangle Pk, NC 27709 USA

Afshari, CA
论文数: 0 引用数: 0
h-index: 0
机构: NIEHS, Res Triangle Pk, NC 27709 USA
[7]
Advances in toxicogenomics
[J].
Hayes, KR
;
Bradfield, RA
.
CHEMICAL RESEARCH IN TOXICOLOGY,
2005, 18 (03)
:403-414

Hayes, KR
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Wisconsin, Sch Med, McArdle Lab Canc Res, Madison, WI 53706 USA Univ Wisconsin, Sch Med, McArdle Lab Canc Res, Madison, WI 53706 USA

Bradfield, RA
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Wisconsin, Sch Med, McArdle Lab Canc Res, Madison, WI 53706 USA Univ Wisconsin, Sch Med, McArdle Lab Canc Res, Madison, WI 53706 USA
[8]
Idiosyncratic drug hepatotoxicity
[J].
Kaplowitz, N
.
NATURE REVIEWS DRUG DISCOVERY,
2005, 4 (06)
:489-499

Kaplowitz, N
论文数: 0 引用数: 0
h-index: 0
机构:
Univ So Calif, Keck Sch Med, Res Ctr Liver Dis, Los Angeles, CA 90033 USA Univ So Calif, Keck Sch Med, Res Ctr Liver Dis, Los Angeles, CA 90033 USA
[9]
Can the pharmaceutical industry reduce attrition rates?
[J].
Kola, I
;
Landis, J
.
NATURE REVIEWS DRUG DISCOVERY,
2004, 3 (08)
:711-715

Kola, I
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, Basic Res, Rahway, NJ 07075 USA

Landis, J
论文数: 0 引用数: 0
h-index: 0
机构: Merck Res Labs, Basic Res, Rahway, NJ 07075 USA
[10]
A toxicogenomic approach to drug-induced phospholipidosis:: Analysis of its induction mechanism and establishment of a novel in vitro screening system
[J].
Sawada, H
;
Takami, K
;
Asahi, S
.
TOXICOLOGICAL SCIENCES,
2005, 83 (02)
:282-292

Sawada, H
论文数: 0 引用数: 0
h-index: 0
机构: Takeda Pharmaceut Co Ltd, Div Pharmaceut Res, Biomed Res Labs, Yodogawa Ku, Osaka 5328686, Japan

Takami, K
论文数: 0 引用数: 0
h-index: 0
机构: Takeda Pharmaceut Co Ltd, Div Pharmaceut Res, Biomed Res Labs, Yodogawa Ku, Osaka 5328686, Japan

Asahi, S
论文数: 0 引用数: 0
h-index: 0
机构: Takeda Pharmaceut Co Ltd, Div Pharmaceut Res, Biomed Res Labs, Yodogawa Ku, Osaka 5328686, Japan