Neuroprotective effects of lamotrigine enhanced by flunarizine in gerbil global ischemia

被引：19

作者：

Lee, YS ^{[1
]}

Yoon, BW ^{[1
]}

Roh, JK ^{[1
]}

机构：

[1] Seoul City Boramae Hosp, Dept Neurol, Dongjak Gu, Seoul 156012, South Korea

来源：

NEUROSCIENCE LETTERS | 1999年 / 265卷 / 03期

关键词：

global ischemia; cerebral infarct; lamotrigine; flunarizine; neuroprotection; gerbil;

D O I：

10.1016/S0304-3940(99)00225-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined whether the anti-ischemic effect of lamotrigine (LTG), which inhibits the presynapic sodium channel, could be enhanced by the calcium channel blocker-flunarizine (FNR) in cerebral ischemia. Global ischemia was induced in Mongolian gerbils for 5 min under the monitoring of scalp temperature. LTG and FNR were administered intraperitoneally 1 h before ischemia. After 7 days, animals were killed and viable neurons in CA1 area were counted. LTG treated group showed significant protective effects compared to control group (P < 0.01). These effects were more prominent in group treated with LTG and FNR (P = 0.01). Combination of two drugs did not increase the mortality rate compared to single-treated group. Those results show that a synergistic reduction of neuronal death can be achieved by combination of LTG and FNR without serious adverse reaction. (C) 1999 Published by Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：215 / 217

页数：3

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