Neuropsychological and neurophysiological findings in individuals suspected to be at risk for schizophrenia:: preliminary results from the Basel early detection of psychosis study -: Fruherkennung von Psychosen (FEPSY)

被引：49

作者：

Gschwandtner, U ^{[1
]}

Aston, J ^{[1
]}

Borgwardt, S ^{[1
]}

Drewe, M ^{[1
]}

Feinendegen, C ^{[1
]}

Lacher, D ^{[1
]}

Lanzarone, A ^{[1
]}

Stieglitz, RD ^{[1
]}

Riecher-Rössler, A ^{[1
]}

Gediga, G ^{[1
]}

Schöttke, H ^{[1
]}

Hänsgen, KD ^{[1
]}

Zimmermann, P ^{[1
]}

Fimm, B ^{[1
]}

机构：

[1] Kantonsspital Basel, Univ Psychiat Outpatient Dept, CH-4031 Basel, Switzerland

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 2003年 / 108卷 / 02期

关键词：

schizophrenia; psychotic disorders; neuropsychological tests; eye movement; motor skills;

D O I：

10.1034/j.1600-0447.2003.00157.x

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: Our study aims to establish a scientific basis for the very early detection of patients at risk for schizophrenia during the nonspecific prodromal phase of the disorder and to predict its outbreak. Method: A multidomain approach is used. After screening, approved psychopathological, neurophysiological, neuropsychological and neuroradiological investigations are used to assess a sample of individuals suspected to be at risk for schizophrenia. Results: Neuropsychological and fine motor functioning tests as well as eye movement measurements showed statistically significant differences (P < 0.01) between individuals suspected to be at risk for schizophrenia and healthy controls. Conclusion: Individuals suspected to be at risk for schizophrenia show specific impairments in various investigations including neuropsychological and fine motor functioning tests as well as eye movement measurements. A set of methods sensitive to even subtle changes in normal functioning may prove useful in predicting the subsequent outbreak of schizophrenia.

引用

页码：152 / 155

页数：4

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