Gene regulation - Insulators and boundaries: Versatile regulatory elements in the eukaryotic genome

被引：289

作者：

Bell, AC ^{[1
]}

West, AG ^{[1
]}

Felsenfeld, G ^{[1
]}

机构：

[1] NIDDKD, Bethesda, MD 20892 USA

来源：

SCIENCE | 2001年 / 291卷 / 5503期

关键词：

D O I：

10.1126/science.291.5503.447

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Insulators mark the boundaries of chromatin domains by limiting the range of action of enhancers and silencers. Although the properties of insulators have been well studied, their role in vivo has Largely been a subject of speculation. Recent results make it possible to ascribe specific and essential functions to the insulators of Drosophila, yeast, and vertebrates. In some cases, insulator activity can Se modulated by nearby regulatory elements, bound cofactors, or covalent modification of the DNA. Not simply passive barriers, insulators are active participants in eukaryotic gene regulation.

引用

页码：447 / 450

页数：4

共 52 条

[1]

Barges S, 2000, DEVELOPMENT, V127, P779

[2] Stopped at the border: boundaries and insulators [J].