Gfi-1: another piece in the HSC puzzle

被引：9

作者：

Cellot, S ^{[1
]}

Sauvageau, G ^{[1
]}

机构：

[1] Univ Montreal, Inst Res Immunol & Canc, Montreal, PQ H3C 3J7, Canada

来源：

TRENDS IN IMMUNOLOGY | 2005年 / 26卷 / 02期

关键词：

D O I：

10.1016/j.it.2004.12.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent work addresses the complex issue of stem cell regulation mechanisms. Both groups involved have studied the role of. Gfi-1 in preserving the functional integrity of the adult hematopoietic stem cell (HSC) pool through a series of experiments, including phenotypic analysis of the primitive hematopoietic compartment, transplantation assays and cell cycle analyses. The results suggest that Gfi-1 deficiency leads to an exhaustion of HSCs in the adult mouse bone marrow, presumably through unrestricted cycling of these cells.

引用

页码：68 / 71

页数：4

共 19 条

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