Serum glycated albumin levels, but not glycated hemoglobin, is low in relation to glycemia in non-diabetic men with nonalcoholic fatty liver disease with high alanine aminotransferase levels

Objectives: We have reported that serum glycated albumin (GA) levels are low in obese subjects, smokers and hyperuricemic subjects in whom high sensitive CRP (hs-CRP) is elevated. Because patients with nonalcoholic fatty liver disease with high alanine aminotransferase (ALT) levels are reported to show high levels of hs-CRP, the relationship between serum ALT and serum GA levels was investigated. Design and methods: This study comprised 196 non-diabetic men without drinking habit. Results: Compared with the normal ALT group (serum ALT <= 30 U/L; n=158), the high ALT group (serum ALT >30 U/L; n=38) had significantly higher fasting plasma glucose (PG), OGTT 2-h PG and HbA(1C) levels. Meanwhile, serum GA was significantly lower, and hs-CRP was significantly higher in the high ALT group. Conclusions: The results obtained indicate that serum GA is under a negative control of hs-CRP in subjects with high ALT without drinking habit. (C) 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.