Benzimidazo[1,2-c][1,2,3]thiadiazole-7-sulfonamides as inhibitors of carbonic anhydrase

被引：25

作者：

Dudutiene, Virginija ^{[1
]}

Baranauskiene, Lina ^{[1
]}

Matulis, Daumantas ^{[1
]}

机构：

[1] Inst Biotechnol, Lab Biothermodynam & Drug Design, LT-02241 Vilnius, Lithuania

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 12期

关键词：

aromatic sulfonamides; binding enthalpy; observed binding constant; carbonic anhydrase; inhibition;

D O I：

10.1016/j.bmcl.2007.03.100

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of benzimidazo[1,2-c][1,2,3]thiadiazole-7-sulfonamides were synthesized and their binding to two carbonic anhydrase isozymes measured by isothermal titration calorimetry (ITC). Human carbonic anhydrase I (hCAI) and bovine carbonic anhydrase 11 (bCAII) bound the inhibitors with observed association constants in the range from 1.1x10(6) to 2.6 x 10(7) M-1. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：3335 / 3338

页数：4

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