Benzimidazo[1,2-c][1,2,3]thiadiazole-7-sulfonamides as inhibitors of carbonic anhydrase

被引:25
作者
Dudutiene, Virginija [1 ]
Baranauskiene, Lina [1 ]
Matulis, Daumantas [1 ]
机构
[1] Inst Biotechnol, Lab Biothermodynam & Drug Design, LT-02241 Vilnius, Lithuania
关键词
aromatic sulfonamides; binding enthalpy; observed binding constant; carbonic anhydrase; inhibition;
D O I
10.1016/j.bmcl.2007.03.100
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A series of benzimidazo[1,2-c][1,2,3]thiadiazole-7-sulfonamides were synthesized and their binding to two carbonic anhydrase isozymes measured by isothermal titration calorimetry (ITC). Human carbonic anhydrase I (hCAI) and bovine carbonic anhydrase 11 (bCAII) bound the inhibitors with observed association constants in the range from 1.1x10(6) to 2.6 x 10(7) M-1. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码:3335 / 3338
页数:4
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