p53 exon 7 mutations as a predictor of poor prognosis in patients with colorectal cancer

被引：25

作者：

Iniesta, P

Vega, FJ

Caldés, T

Massa, MJ

de Juan, C

Cerdán, FJ

Sánchez, A

López, JA

Torres, AJ

Balibrea, JL

Benito, M ^{[1
]}

机构：

[1] Univ Complutense, Fac Farm, Dept Bioquim & Biol Mol, E-28040 Madrid, Spain

[2] Hosp Univ San Carlos, Serv Inmunol, Madrid 28040, Spain

[3] Hosp Univ San Carlos, Serv Cirugia 2, Madrid 28040, Spain

[4] Hosp Univ San Carlos, Serv Anat Patol, Madrid 28040, Spain

来源：

CANCER LETTERS | 1998年 / 130卷 / 1-2期

关键词：

colorectal cancer; p53; exon; 7; mutations; prognosis;

D O I：

10.1016/S0304-3835(98)00138-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have studied 61 resected colorectal adenocarcinomas in order to investigate p53 mutations as a prognostic factor for this pathology. Mutations in exons 5-9 of the p53 gene were analyzed by the polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) technique followed by sequencing. Our data indicate that p53 exon 7 mutations were prevalent in the latest stages of colorectal carcinogenesis and patients bearing this alteration had the worst prognosis. Therefore, according to our results, mutations affecting exon 7 of the p53 gene could be considered as a useful marker of biological aggressiveness for colorectal cancer. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：153 / 160

页数：8

共 34 条

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