Candida proteases and their inhibition:: Prospects for antifungal therapy

被引：42

作者：

Stewart, K ^{[1
]}

Abad-Zapatero, C ^{[1
]}

机构：

[1] Abbott Labs, Dept Biol Struct, Abbott Pk, IL 60064 USA

来源：

CURRENT MEDICINAL CHEMISTRY | 2001年 / 8卷 / 08期

关键词：

D O I：

10.2174/0929867013372698

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The rationale for inhibition of the secreted acid proteases (SAP) of Candida fungal species as a novel antifungal strategy is outlined. Enzyme structure-activity relationship data regarding the inhibitor A-70450 are described along with results from in vivo antifungal assays. Developments from protein X-ray crystallographic studies, SAP knock-out genetic studies, and the importance of these new results for drug discovery are reviewed. Finally, inhibition of the Candida SAP enzymes with HIV protease inhibitors and a proposed role in candidiasis of AIDS patients is discussed.

引用

页码：941 / 948

页数：8

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